Zolmitriptan

Name: Zolmitriptan
SKU: Z5745
Availability: InStock

Product ID Z5745

Cas No. 139264-17-8

Purity ≥99%

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Description

Zolmitriptan is a synthetic tryptamine derivative that acts as an agonist at 5-HT1B/1D receptors, binding primarily in the ventral palladium, external globus pallidus, substantia nigra, visual cortex, and nucleus accumbens. This compound displays anti-inflammatory, anti-migraine, and neuroprotective activities. Zolmitriptan treats migraines, inhibiting dilation and inflammation of cranial vessels. This compound also alters NMDA receptor-evoked cGMP and NO signaling. In addition to its modulation of neurotransmitter levels, zolmitriptan inhibits action potential discharge of trigeminal neurons, suggesting antinociceptive activity as well. TEST!!!!!!

Product Info

Cas No.	139264-17-8
Purity	≥99%
Formula	C₁₆H₂₁N₃O₂
Formula Wt.	287.36
Chemical Name	(S)-4-({3-[2-(dimethylamino)ethyl]-1H-indol-5-yl}methyl)-1,3-oxazolidin-2-one
IUPAC Name	(4S)-4-[[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]methyl]-1, 3-oxazolidin-2-one
Solubility	slightly soluble in water (1.3 mg/mL at 250°C) but shows greater solubility in 0.1M hydrochloric acid. Zolmitriptan has a pKa of 9.6.
Appearance	White to off white powder

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Store Temp	Ambient
Ship Temp	Ambient

Downloads

MSDS	Z5745 MSDS PDF
Info Sheet	Z5745 Info Sheet PDF

References

Lindhe O, Almqvist P, Kågedal M, et al. Autoradiographic Mapping of 5-HT(1B/1D) Binding Sites in the Rhesus Monkey Brain Using [carbonyl-C]zolmitriptan. Int J Mol Imaging. 2011;2011:694179. PMID: 22013519.

Kayser V, Latrémolière A, Hamon M, et al. N-methyl-D-aspartate receptor-mediated modulations of the anti-allodynic effects of 5-HT1B/1D receptor stimulation in a rat model of trigeminal neuropathic pain. Eur J Pain. 2011 May;15(5):451-8. PMID: 20965753.

Stepień A, Chalimoniuk M, Strosznajder J. Serotonin 5HT1B/1D receptor agonists abolish NMDA receptor-evoked enhancement of nitric oxide synthase activity and cGMP concentration in brain cortex slices. Cephalalgia. 1999 Dec;19(10):859-65. PMID: 10668104.

Cumberbatch MJ, Hill RG, Hargreaves RJ. The effects of 5-HT1A, 5-HT1B and 5-HT1D receptor agonists on trigeminal nociceptive neurotransmission in anaesthetized rats. Eur J Pharmacol. 1998 Nov 27;362(1):43-6. PMID: 9865528.

Pascual J. Mechanism of action of zolmitriptan. Neurologia. 1998 Oct;13 Suppl 2:9-15. PMID: 9859690.

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Zolmitriptan

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