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Vinorelbine is a semi-synthetic vinca alkaloid originally found in Catharanthus that exhibits anticancer chemotherapeutic activity. Vinorelbine binds β-tubulin and stimulates microtubule depolymerization, acting as an anti-mitotic. Vinorelbine is clinically used to treat breast cancer and non-small cell lung cancer (NSCLC). In osteosarcoma cells, vinorelbine downregulates expression of cyclin D1 and upregulates expression of p53, inhibiting cell growth.
| Cas No. | 125317-39-7 |
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| Purity | ≥98% |
| Formula | C45H54N4O8 • 2C4H6O6 |
| Formula Wt. | 1079.10 |
| Chemical Name | 3',4'-Didehydro-4'-deoxy-C'-norvincaleukoblastine ditartrate |
| Synonym | Eunades, Navelbine |
| Melting Point | 219°C |
| Solubility | Soluble in water and ethanol. |
| Appearance | Off-white or light brown powder |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
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| Info Sheet |
Capasso A. Vinorelbine in cancer therapy. Curr Drug Targets. 2012 Jul;13(8):1065-71. PMID: 22594474.
Roncuzzi L, Marti G, Baiocchi D, et al. Effect of Vinorelbine on cell growth and apoptosis induction in human osteosarcoma in vitro. Oncol Rep. 2006 Jan;15(1):73-7. PMID: 16328036.