LKT Labs

Biochemicals for Life Science Research

Vidarabine Monophosphate

Vidarabine Monophosphate

Product ID V3213
Cas No. 29984-33-6
Purity ≥98.0%
Product Unit SizeCostQuantityStock
10 mg $45.00 In stock
100 mg $90.00 In stock
500 mg $224.70 In stock
1 g $337.30 In stock
Bulk Quote

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Description

Vidarabine is a long-acting antiviral originally found in the marine sponge Tethyra crypta. Vidarabine is an adenosine analog in which the D-ribose constituent is replaced by D-arabinose, preventing formation of phosphodiester bridges upon incorporation into DNA. This compound is a substrate for and inhibitor of viral DNA polymerase and may also inhibit ribonucleotide reductase. Vidarabine is used to treat subjects with severe chronic Epstein-Barr virus, herpes simplex virus, or human papilloma virus, as well as immunocompromised patients with adenovirus-induced hemorrhagic cystitis.

Product Info

Cas No.

29984-33-6
Purity

≥98.0%
Formula

C10H14N5O7P
Formula Wt.

347.22
IUPAC Name

[(2R,3S,4S,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate
Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

V3213 MSDS PDF
Info Sheet

V3213 Info Sheet PDF

References

Whitley RJ. The use of antiviral drugs during the neonatal period. Clin Perinatol. 2012 Mar;39(1):69-81. PMID: 22341538.

Wilhelmus KR. Antiviral treatment and other therapeutic interventions for herpes simplex virus epithelial keratitis. Cochrane Database Syst Rev. 2010 Dec 8;(12):CD002898. PMID: 21154352.

Sagar S, Kaur M, Minneman KP. Antiviral lead compounds from marine sponges. Mar Drugs. 2010 Oct 11;8(10):2619-38. PMID: 21116410.

Kurosaki K, Miwa N, Yoshida Y, et al. Therapeutic basis of vidarabine on adenovirus-induced haemorrhagic cystitis. Antivir Chem Chemother. 2004 Sep;15(5):281-5. PMID: 15535050.

Niwa K, Tagami K, Lian Z, et al. Topical vidarabine or 5-fluorouracil treatment against persistent HPV in genital (pre)cancerous lesions. Oncol Rep. 2003 Sep-Oct;10(5):1437-41. PMID: 12883720.

Kimura H, Morita M, Tsuge I, et al. Vidarabine therapy for severe chronic active Epstein-Barr virus infection. J Pediatr Hematol Oncol. 2001 Jun-Jul;23(5):294-9. PMID: 11464986.

Nimit Y, Law J, Daly JW. Binding of 2',5'-dideoxyadenosine to brain membranes. Comparison to P-site inhibition of adenylate cyclase. Biochem Pharmacol. 1982 Oct 15;31(20):3279-87. PMID: 6983353.

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