Verdinexor

Name: Verdinexor
SKU: V182685
Availability: InStock

Product ID V182685

Cas No. 1392136-43-4

Purity ≥99%

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Description

Verdinexor is a selective inhibitor of nuclear transport (SINE) that targets the export protein CRM1(also known as XPO1). Verdinexor has shown cytotoxic activity in canine non-Hodgkin lymphoma and melanoma cells, including inhibition of proliferation and colony formation, induction of apoptosis, downregulation of CRMI expression, and modulation of p53 expression. Treatment of BALB/c female mice with verdinexor post-infection with influenza virus was shown to reduce pulmonary pro-inflammatory cytokine expression and moderate leukocyte infiltration. In addition, ferrets treated orally showed reduced lung pathology, virus burden, and inflammatory cytokine expression.
TEST!!!!!!

Product Info

Cas No.	1392136-43-4
Purity	≥99%
Formula	C₁₈H₁₂F₆N₆O
Formula Wt.	442.33
Chemical Name	(2Z)-3-(3-(3,5-Bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-N'-(pyridin-2-yl)prop-2-enehydrazide
IUPAC Name	(2Z)-3-{3-[3,5-Bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl}-N'-(2-pyridinyl)acrylohydrazide
Synonym	KPT-335, 2-Propenoic acid, 3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-, 2-(2-pyridinyl)hydrazide, (2Z)-
Solubility	Insoluble in water. Soluble in DMSO, 80 mg/mL (180 mM).

Shipping and Storage

Store Temp	4°C
Ship Temp	Ambient

Downloads

MSDS	V182685 MSDS PDF
Info Sheet	V182685 Info Sheet PDF

References

Gravina GL, Senapedis W, McCauley D, et al. Nucleo-cytoplasmic transport as a therapeutic target of cancer. J Hematol Oncol. 2014 Dec 5;7:85. PMID: 25476752.

Perwitasari O, Johnson S, Yan X, et al. Antiviral efficacy of verdinexor in vivo in two animal models of influenza A virus infection. PLoS One. 2016 Nov 28;11(11):e0167221. PMID: 27893810.

Breit MN, Kisseberth WC, Bear MD, et al. Biologic activity of the novel orally bioavailable selective inhibitor of nuclear export (SINE) KPT-335 against canine melanoma cell lines. BMC Vet Res. 2014 Jul 15;10:160. PMID: 25022346.

Perwitasari O, Johnson S, Yan X, et al. Verdinexor, a novel selective inhibitor of nuclear export, reduces influenza A virus replication in vitro and in vivo. J Virol. 2014 Sept 1;88(17):10228-10243. PMID: 24965445.

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Verdinexor

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