LKT Labs

Biochemicals for Life Science Research

Tropodithietic Acid

Tropodithietic Acid

Product ID T698579
Cas No. 750590-18-2
Purity ≥99%
Product Unit SizeCostQuantityStock
1 mg $176.40 Please Inquire
5 mg $705.60 Please Inquire
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Description

Tropodithietic acid is an antibiotic produced by various marine proteobacteria. Tropodithietic acid has been found to have the same activity as endogenous N-acyl-homoserine lactones and can trigger quorum-sensing in marine bacterium. Furthermore, it has been shown that long-term exposure to tropodithietic acid does not result in antibacterial resistant or tolerant strains. In addition, screening of the NCI-60 human tumor cell lines showed tropodithietic acid to have strong growth-inhibitory anticancer activity.

Product Info

Cas No.

750590-18-2
Purity

≥99%
Formula

C8H4O3S2
Formula Wt.

212.24
Chemical Name

3-Oxo-8,9-dithiabicyclo[5.2.0]nona-1,4,6-triene-2-carboxylic acid
IUPAC Name

3-Oxo-8,9-dithiabicyclo[5.2.0]nona-1,4,6-triene-2-carboxylic acid
Synonym

TDA
Solubility

Soluble in polar organic solvents, such as DMSO, Methanol, Acetone
Appearance

Orange powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

T698579 MSDS PDF
Info Sheet

T698579 Info Sheet PDF

References

Beyersmann PG, Tomasch J, Son K, et al. Dual function of tropodithietic acid as antibiotic and signaling molecule in global gene regulation of the probiotic bacterium Phaeobacter inhibens. Sci Rep. 2017 Apr 7;7(1):730. PMID: 28389641.

Rasmussen BB, Grotkjaer T, D’Alvise PW, et al. Vibrio anguillarum is genetically and phenotypically unaffected by long-term continuous exposure to the antibacterial compound tropodithietic acid. Appl Environ Microbiol. 2016 Jul 15;82(15):4802-4810. PMID: 27235441.

Wilson MZ, Wang R, Gitai Z, et al. Mode of action and resistance studies unveil new roles for tropodithietic acid as an anticancer agent and the gamma-glutamyl cycle as a proton sink. Proc Natl Acad Sci USA. 2016 Feb 9;113(6):1630-1635. PMID: 26802120.

Porsby CH, Webber MA, Nielsen KF, et al. Resistance and tolerance to tropodithietic acid, an antimicrobial in aquaculture, is hard to select. Antimicrob Agents Chemother. 2011 Apr;55(4):1332-1337. PMID: 21263047.

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