• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Awaiting product image

Topotecan Hydrochloride

Product ID T5761
Cas No. 119413-54-6
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $44.80 In stock
5 mg $67.40 In stock
10 mg $81.00 In stock
50 mg $137.90 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Topotecan is an anticancer chemotherapeutic compound that inhibits topoisomerase I and is clinically used to treat various cancers. Topotecan induces apoptosis in retinocytoma cells and ovarian cancer cells. TEST!!!!!!

Product Info

Cas No.

119413-54-6

Purity

≥98%

Formula

C23H25N3O5 • HCl

Formula Wt.

457.91

Chemical Name

(4S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9- dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]- quinoline-3,14(4H,12H)-dione hydrochloride

Synonym

Hycamtin, NSC-609669, SKF-104864A

Melting Point

213-218°C(dec.)

Solubility

Soluble in methanol, water (92 mg/mL at 25 °C), DMSO (92 mg/mL at 25 °C), ethanol (<1 mg/mL at 25 °C), and 1: 1 solution of DMSO: PBS (pH 7.2, ~0.5 mg/mL).

Appearance

Pale Yellow Crystal Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

T5761 MSDS PDF

Info Sheet

T5761 Info Sheet PDF

References

Attia SM, Ahmad SF, Abd-Ellah MF, et al. Germ cell mutagenicity of topoisomerase I inhibitor topotecan detected in the male mouse-dominant lethal study. Food Chem Toxicol. 2013 Dec;62:470-4. PMID: 24036143.

Zhang M, Shan BE, Yuan NF, et al. Effect of topotecan on retinocytoma cell apoptosis and expression of Livin and PTEN. Chin Med J (Engl). 2013 Jan;126(2):340-4. PMID: 23324287.

Caltová K, Cervinka M. Antiproliferative effects of selected chemotherapeutics in human ovarian cancer cell line A2780. Acta Medica (Hradec Kralove). 2012;55(3):116-24. PMID: 23297519.

Sonabend AM, Stuart RM, Yun J, et al. Prolonged intracerebral convection-enhanced delivery of topotecan with a subcutaneously implantable infusion pump. Neuro Oncol. 2011 Aug;13(8):886-893. PMID: 21750007.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • B1874

    Bestatin Hydrochloride

    Dipeptide; aminopeptidase (N/CD13) inhibitor.

    ≥98%
  • O486181

    Omeprazole Related Compound B

    ≥99%
  • E7658

    Etoposide Phosphate

    Epipodophyllotoxin derivative; topoisomerase II...

    ≥98%
  • Q8134

    Quinapril Hydrochloride

    ACE inhibitor.

    ≥98%
  • H9611

    Hydrocortisone

    Endogenous steroid hormone involved in stress s...

    ≥98%
  • S3345

    Silymarin

    Flavonolignan mixture found in Silybum (milk th...

    ≥70%
  • D5869

    Doripenem Hydrate

    β-lactam carbapenem; penicillin binding protei...

    ≥98%
  • L5749

    Lomefloxacin Hydrochloride

    Fluoroquinolone; topoisomerase IV and bacterial...

    ≥98%
  • G4798

    Glycitein

    Aglycone isoflavone found in soy and red clover...

    ≥98%
  • A5193

    Amygdalin

    Glucoside found in stone fruits and apples.

    ≥98%
  • F5770

    Formononetin

    Isoflavone found in legumes such as soy.

    ≥90%
  • E5477

    Entinostat

    Benzamide; HDAC1 inhibitor.

    ≥98%
  • D3374

    Disulfiram

    Aldehyde dehydrogenase, 26S proteasome, MGMT in...

    ≥98%
  • L5873

    Losartan Potassium

    AT1 antagonist.

    ≥98%
  • S0831

    S-(−)-Schisandrin B

    Found in Schisandra.

    ≥98%
  • E5369

    Enrofloxacin

    Fluoroquinolone; bacterial DNA gyrase inhibitor...

    ≥98%
  • G1855

    Gentiopicroside

    Secoiridoid glycoside found in Gentiana and Cep...

    ≥97%
  • M1560

    Methyl Caffeate

    Polyphenol found in species of Solanum and Magn...

    ≥98%
  • M3377

    Mitomycin C

    Alkaloid produced by Streptomyces, DNA cross-li...

    ≥98%
  • P6858

    Procarbazine Hydrochloride

    Hydrazine derivative, DNA alkylator; MAO inhibi...

    ≥97%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2026 LKT Laboratories, All Rights Reserved - Products for research use only