LKT Labs

Biochemicals for Life Science Research

Tolvaptan

Tolvaptan

Product ID T5847
Cas No. 150683-30-0
Purity ≥98%
Product Unit SizeCostQuantityStock
25 mg $79.10 In stock
100 mg $173.30 In stock
500 mg $535.60 In stock
Bulk Quote

Quicklinks

Description

Tolvaptan is an inhibitor of the vasopressin receptor subtype V2; it acts as a diuretic, inhibiting reabsorption of water in the kidney without loss of sodium. Tolvaptan is a clinically effective diuretic used in congestive heart failure (CHF) and severe chronic kidney disease that does not induce hypernatremia. This compound can also be used to treat the severe or chronic hyponatremia stemming from syndrome of inappropriate antidiuretic hormone secretion (SIADH) that occurs after traumatic brain injury.

Product Info

Cas No.

150683-30-0
Purity

≥98%
Formula

C26H25ClN2O3
Formula Wt.

448.94
Chemical Name

N-(4-{[(5R)-7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]carbonyl}-3-methylphenyl)-2-methylbenzamide
IUPAC Name

N-[4-(7-chloro-5-hydroxy-2,3,4, 5-tetrahydro-1-benzazepine-1-carbonyl)-3-methylphenyl]-2-methylbenzamide
Synonym

OPC-41061
Melting Point

226°C
Appearance

Off-white to yellow powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

T5847 MSDS PDF
Info Sheet

T5847 Info Sheet PDF

References

Otsuka T, Sakai Y, Ohno D, et al. The effects of tolvaptan on patients with severe chronic kidney disease complicated by congestive heart failure. Clin Exp Nephrol. 2013 Mar 13. [Epub ahead of print]. PMID: 23483323.

Graziani G, Cucchiari D, Aroldi A, et al. Syndrome of inappropriate secretion of antidiuretic hormone in traumatic brain injury: when tolvaptan becomes a life saving drug. J Neurol Neurosurg Psychiatry. 2012 May;83(5):510-2. PMID: 22323742

Gheorghiade M, Teerlink JR, Mebazaa A. Pharmacology of new agents for acute heart failure syndromes. Am J Cardiol. 2005 Sep 19;96(6A):68G-73G. PMID: 16181825.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • D1869

    Deracoxib

    NSAID; COX-2 inhibitor.
    ≥99%
  • K1978

    Ketorolac Tromethamine

    NSAID; COX-1/2 inhibitor.
    ≥98%
  • C1868

    Cerebellin

    Peptide, involved in synapse formation and cell ad...
    ≥95%
  • R8122

    Rufloxacin Hydrochloride

    Fluoroquinolone; topoisomerase IV and bacterial DN...
    ≥98%
  • A4000

    AK-1

    SIRT2 inhibitor.
    ≥99%
  • C5773

    Cortistatin-14

    Endogenous neuropeptide, somatostatin analog; soma...
    ≥95%
  • H9613

    N-(4-Hydroxyphenyl)retinamide

    Retinol (vitamin A) analog, binds RBP4; Des1 inhib...
    ≥98%
  • T3098

    Thymosin β-4 Acetate

    Endogenous peptide; actin polymerization inhibitor...
    ≥95%
  • SC7056

    Snake venom – Crotalus durissus terrificus

    Snake venom found in Crotalus durrisus terrificus;...
    ≥98%
  • G8800

    GW-788388

    ALK5 (activin-like) antagonist.
    ≥98%
  • S1612

    Sedanolide

    Phthalide found in celery seeds; COX-1, COX-2, top...
    ≥98%
  • G5752

    Gonadorelin Acetate

    Synthetic peptide, GnRH derivative; GnRH agonist.
    ≥95%
  • T0299

    Tazobactam Sodium

    β-lactamase inhibitor.
    ≥98%
  • R5700

    Ro 61-8048

    Kynurenine 3-hydroxylase inhibitor.
    ≥99%
  • P0001

    P1 Peptide

    Octapeptide, prevents EGFR-PLCγ association.
    ≥95%
  • P6004

    PP-242

    Dual mTORC1/mTORC2 inhibitor.
    ≥98%
  • B1855

    O6-Benzylguanine

    MGMT inhibitor.
    ≥98%
  • R3477

    Ritodrine Hydrochloride

    Phenylethylamine; β2-adrenergic agonist, SK/BK an...
    ≥98%
  • C5646

    Collagen Binding Fragment

    Peptide, fibronectin fragment, used as fibronectin...
    ≥95%
  • M5753

    Monensin Sodium

    Polyether ionophore, autophagy inhibitor.
    ≥98%