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Tolmetin is a pyrrole non-steroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory and analgesic activities. Tolmetin inhibits COX-1 and COX-2, preventing prostaglandin E (PGE) production; it is clinically used to treat rheumatoid arthritis and osteoarthritis. TEST!!!!!!
| Cas No. | 64490-92-2 |
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| Purity | ≥98% |
| Formula | C15H14NNaO3 • 2H2O |
| Formula Wt. | 315.30 |
| Chemical Name | 1-Methyl-5-(4-methylbenzoyl)-1H-pyrrole-2-acetic acid sodium salt dihydrate |
| IUPAC Name | sodium;2-[1-methyl-5-(4-methylbenzoyl)pyrrol-2-yl]acetate |
| Synonym | Tolmetin sodium salt dihydrate, Reutol, Tolectine, Tolmene |
| Melting Point | 155-157 (dec.) |
| Solubility | Soluble in water. |
| Appearance | Off-white powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Fernandes E, Costa D, Toste SA, et al. In vitro scavenging activity for reactive oxygen and nitrogen species by nonsteroidal anti-inflammatory indole, pyrrole, and oxazole derivative drugs. Free Radic Biol Med. 2004 Dec 1;37(11):1895-905. PMID: 15528048.
Davies J, Dixon AS, Steele CE. Tolmetin sodium and indomethacin in the treatment of osteoarthrosis of the hip: a double-blind crossover study. Curr Med Res Opin. 1980;7(2):115-20. PMID: 7002480.
Cordrey LJ. Tolmetin sodium, a new anti-arthritis drug: double-blind and long-term studies. J Am Geriatr Soc. 1976 Oct;24(10):440-6. PMID: 61224.