Tobramycin Sulfate

Name: Tobramycin Sulfate
SKU: T5605
Availability: InStock

Product ID T5605

Cas No. 79645-27-5

Purity ≥98%

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Description

Tobramycin is an aminoglycoside antibiotic that exhibits antibacterial and anti-inflammatory activities. Tobramycin prevents formation of the 70S bacterial ribosomal complex, inhibiting protein translation; it is highly effective in the treatment of Pseudomonas infections. In vitro, tobramycin inhibits T cell and neutrophil migration. In separate cellular models, this compound also decreases activation of NF-κB, expression of MUC5AC, and phosphorylation of ERK and p38 MAPK. TEST!!!!!!

Product Info

Cas No.	79645-27-5
Purity	≥98%
Formula	(C₁₈H₃₇N₅O₉)₂ • 5H₂SO₄
Formula Wt.	1425.45
Chemical Name	O-3-Amino-3-deoxy-α-D-glucopyranosyl-(1->6)-O- [2,6-diamino-2,3,6-trideoxy-α-D-ribo-hexopyranosyl- (1->4)]-2-deoxy-D-streptamine sulfate
IUPAC Name	4-amino-2-[4, 6-diamino-3-[3-amino-6-(aminomethyl)-5-hydroxyoxan-2-yl]oxy-2- hydroxycyclohexyl]oxy-6-(hydroxymethyl)oxane-3,5-diol;sulfuric acid
Synonym	Gernebcin, Nebcin, Nebicina, Tobra, Tobradistin
Melting Point	287°C(dec.)
Solubility	Soluble in water (50 mg/mL).
Appearance	White Crystal Powder

Shipping and Storage

Store Temp	Ambient
Ship Temp	Ambient

Downloads

MSDS	T5605 MSDS PDF
Info Sheet	T5605 Info Sheet PDF

References

Papich MG. Antibiotic treatment of resistant infections in small animals. Vet Clin North Am Small Anim Pract. 2013 Sep;43(5):1091-107. PMID: 23890241.

Gziut M, MacGregor HJ, Nevell TG, et al. Anti-inflammatory effects of tobramycin and a copper-tobramycin complex with superoxide dismutase-like activity. Br J Pharmacol. 2013 Mar;168(5):1165-81. PMID: 23072509.

Nakamura S, Yanagihara K, Araki N, et al. High-dose tobramycin inhibits lipopolysaccharide-induced MUC5AC production in human lung epithelial cells. Eur J Pharmacol. 2011 Mar 21. [Epub ahead of print]. PMID: 21414310.

Periti P. Tobramycin--clinical pharmacology and chemotherapy. J Chemother. 1996 Jan;8 Suppl 1:3-30. PMID: 8948764.

King P, Citron DM, Griffith DC, et al. Effect of oxygen limitation on the in vitro activity of levofloxacin and other antibiotics administered by the aerosol route against Pseudomonas aeruginosa from cystic fibrosis patients. Diagn Microbiol Infect Dis. 2010 Feb;66(2):181-186. PMID: 19828274.

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Tobramycin Sulfate

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Description

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