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Thiamphenicol is a chloramphenicol analog that exhibits antibiotic activity. Thiamphenicol inhibits the 50S subunit of the bacterial ribosome, inhibiting protein translation. Thiamphenicol displays antibacterial efficacy against Streptococcus, Staphylococcus, Escherichia, and Haemophilus.
| Cas No. | 2611-61-2 |
|---|---|
| Purity | ≥98% |
| Formula | C14H18Cl2N2O6S • HCl |
| Formula Wt. | 449.7 |
| Chemical Name | 2,2-dichloro-N-[(1R,2R)-2-hydroxy-1-hydroxymethyl- 2-[4-methylsulphonyl)phenyl]ethyl]acetamide glycinate hydrochloride |
| IUPAC Name | [(2R,3R)-2-[(2, 2-dichloroacetyl)amino]-3-hydroxy-3-(4-methylsulfonylphenyl)propyl] 2-aminoacetate;hydrochloride |
| Synonym | Neomyson G HCl, Urfamicin HCl |
| Solubility | Soluble in water and DMF. |
| Appearance | White Crystal Powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| Info Sheet |
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Raymond J, Boutros N, Bergeret M. Role of thiamphenicol in the treatment of community-acquired lung infections. Med Trop (Mars). 2004;64(1):33-8. PMID: 15224555.
Marchese A, Debbia EA, Tonoli E, et al. In vitro activity of thiamphenicol against multiresistant Streptococcus pneumoniae, Haemophilus influenzae and Staphylococcus aureus in Italy. J Chemother. 2002 Dec;14(6):554-61. PMID: 12583545.