LKT Labs

Biochemicals for Life Science Research

TG101348

TG101348

Product ID T2404
Cas No. 936091-26-8
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $75.00 Please Inquire
5 mg $142.60 In stock
10 mg $216.80 Please Inquire
Bulk Quote

Quicklinks

Description

TG101348 is an inhibitor of JAK2 that is currently in clinical trials as a potential treatment for myelofibrosis. TG101348 exhibits immunomodulatory and anticancer chemotherapeutic activities. In cells acquired from acute coronary syndrome patients, TG101348 decreases expression of Th17 cells and increases expression of Treg cells. TG101348 inhibits cellular proliferation of Hodgkin lymphoma cells and mediastinal large B-cell lymphoma cells; in vivo, this compound decreases tumor growth and increases survival. In animal models of myeloproliferative disease, TG101348 decreases hematocrit and leukocyte count, somewhat attenuating myelofibrosis.

Product Info

Cas No.

936091-26-8
Purity

≥98%
Formula

C27H36N6O3S
Formula Wt.

524.68
IUPAC Name

N-(2-Methyl-2-propanyl)-3-{[5-methyl-2-({4-[2-(1-pyrrolidinyl)ethoxy]phenyl}amino)-4-pyrimidinyl]amino}benzenesulfonamide
Synonym

SAR302503, Fedratinib
Solubility

DMSO 100 mg/mL (190.59 mM) Water Insoluble Ethanol Insoluble
Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

T2404 MSDS PDF
Info Sheet

T2404 Info Sheet PDF

References

Zheng Y, Wang Z, Deng L, et al. Modulation of STAT3 and STAT5 activity rectifies the imbalance of Th17 and Treg cells in patients with acute coronary syndrome. Clin Immunol. 2015 Jan 5;157(1):65-77. PMID: 25572535.

Hao Y, Chapuy B, Monti S, et al. Selective JAK2 inhibition specifically decreases Hodgkin lymphoma and mediastinal large B-cell lymphoma growth in vitro and in vivo. Clin Cancer Res. 2014 May 15;20(10):2674-83. PMID: 24610827.

Zhang M, Xu CR, Shamiyeh E, et al. A randomized, placebo-controlled study of the pharmacokinetics, pharmacodynamics, and tolerability of the oral JAK2 inhibitor fedratinib (SAR302503) in healthy volunteers. J Clin Pharmacol. 2014 Apr;54(4):415-21. PMID: 24165976.

Wernig G, Kharas MG, Okabe R, et al. Efficacy of TG101348, a selective JAK2 inhibitor, in treatment of a murine model of JAK2V617F-induced polycythemia vera. Cancer Cell. 2008 Apr;13(4):311-20. PMID: 18394554.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • C9709

    Cycloheximide

    Protein synthesis inhibitor, used to measure prote...
    ≥98%
  • L2876

    Luteinizing Hormone Releasing Hormone III, lamprey

    Peptide hormone found in eels; GnRH agonist, weak ...
    ≥98%
  • B004084

    7,10,13-Trimethyl-10-Deacetyl Baccatin III

    7,10,13-Trimethyl-10-Deacetyl Baccatin III or 10-D...
    ≥95%
  • C0275

    Castanospermine

    O-GlcNAcase inhibitor.
    ≥98%
  • M5727

    Moguisteine

    Potential ATP-sensitive K+ channel blocker, potent...
    ≥98%
  • R1985

    Reveromycin A

    Isoleucyl-tRNA synthase inhibitor, osteoclast prot...
    ≥98%
  • E6257

    Epothilone B

    Microtubule depolymerization inhibitor.
    ≥98%
  • M1564

    S-Methyl-L-cysteine

    Antioxidant found in Brassicaceae family plants.
    ≥99%
  • C6935

    Crizotinib

    ALK, ROS1, c-MET inhibitor.
    ≥98%
  • E4418

    β-Elemene

    Sesquiterpene found in various plant sources.
    ≥98%
  • P0006

    Pituitary Adenylate Cyclase-activating Polypeptide (1-38), human, sheep, rat

    Endogenous peptide, involved in paracrine and auto...
    ≥95%
  • P2515

    3-Phenylpropyl Isothiocyanate

    Synthetic ITC.
    ≥98%
  • N1977

    Neurokinin A (4-10)

    Endogenous neuropeptide, also known as substance K...
    ≥95%
  • N4972

    NMS-873

    Valosin-containing protein inhibitor.
    ≥98%
  • F8250

    Fumitremorgin C

    Mycotoxin found in Aspergillus and Penicillum; ABC...
    ≥98%
  • S8045

    S-Sulforaphane

    Synthetic antioxidant that induces phase II enzyme...
    ≥97%
  • A5070

    Angiotensin Acetate

    Peptide, derivative of AT I, cleavage product of a...
    ≥95%
  • D1624

    Deflazacort

    Oxazoline; glucocorticoid agonist.
    ≥98%
  • W4096

    WKYMVM-NH2

    Synthetic peptide; FPRL1 agonist.
    ≥95%
  • L0249

    Laminin Peptide YIGSR-NH2

    Laminin-derived peptapeptide.
    ≥98%