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Terbinafine is an allylamine that exhibits anticancer, antifungal, and anti-hyperlipidemic activities. Terbinafine inhibits squalene oxidase, preventing synthesis of ergosterol and cholesterol. Terbinafine also inhibits proliferation of oral squamous cell carcinoma cells, inhibiting kinase suppressor of RAS 1 (KSR1).
| Cas No. | 78628-80-5 |
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| Purity | ≥98% |
| Formula | C21H25N • HCl |
| Formula Wt. | 327.90 |
| Chemical Name | N-[(2E)-6,6-Dimethyl-2-hepten-4-ynyl]-N-methyl-1- naphthalenemethanamine hydrochloride |
| IUPAC Name | (E)-N,6, 6-trimethyl-N-(naphthalen-1-ylmethyl)hept-2-en-4-yn-1-amine; hydrochloride |
| Synonym | Lamisil |
| Melting Point | 195-198°C |
| Solubility | Soluble in methanol, methylene chloride or ethanol. |
| Appearance | White or off-white powder |
| Store Temp | 4°C |
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| Ship Temp | Ambient |
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| Info Sheet |
Li B, Lu L, Zhong M, et al. Terbinafine inhibits KSR1 and suppresses Raf-MEK-ERK signaling in oral squamous cell carcinoma cells. Neoplasma. 2013;60(4):406-12. PMID: 23581412.
Nowosielski M, Hoffmann M, Wyrwicz LS, et al. Detailed mechanism of squalene epoxidase inhibition by terbinafine. J Chem Inf Model. 2011 Feb 28;51(2):455-62. PMID: 21229992.
Revankar SG, Nailor MD, Sobel JD. Use of terbinafine in rare and refractory mycoses. Future Microbiol. 2008 Feb;3(1):9-17. PMID: 18230029.