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Tenuazonic acid (TA) is a mycotoxin initially produced by Alternaria fungi and occurs primarily in grains. TA inhibits photosynthesis in chloroplasts and increases generation of ROS such as hydrogen peroxide, superoxide radicals, and hydroxide radicals, resulting in cell destruction and leaf necrosis.
| Cas No. | 610-88-8 |
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| Purity | ≥96% |
| Formula | C10H15NO3 |
| Formula Wt. | 197.23 |
| IUPAC Name | 4-acetyl-2-butan-2-yl-3-hydroxy-1,2-dihydropyrrol-5-one |
| Synonym | 3-Pyrrolin-2-one, 3-acetyl-5-sec-butyl-4-hydroxy-, L- L-Tenuazonic acid |
| Solubility | Soluble in DMSO and ethanol. |
| Appearance | Blue Green Powder |
| Store Temp | 4°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Schwarz C, Kreutzer M, Marko D. Minor contribution of alternariol, alternariol monomethyl ether and tenuazonic acid to the genotoxic properties of extracts from Alternaria alternata infested rice. Toxicol Lett. 2012 Oct 2;214(1):46-52. PMID: 22906495.
Chen S, Yin C, Qiang S, et al. Chloroplastic oxidative burst induced by tenuazonic acid, a natural photosynthesis inhibitor, triggers cell necrosis in Eupatorium adenophorum Spreng. Biochim Biophys Acta. 2010 Mar;1797(3):391-405. PMID: 20026008.