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Tenovin-1 is an inhibitor of sirtuins 1 and 2 (SIRT1/2) that also indirectly activates p53; sirtuins are considered class III histone deacetylases (HDACs). Tenovin-1 exhibits anticancer potential, increasing FOXO3 and p53 expression and inducing apoptosis in cutaneous T-cell lymphoma cells.
| Cas No. | 380315-80-0 |
|---|---|
| Purity | ≥98% |
| Formula | C20H23N3O2S |
| Formula Wt. | 369.48 |
| IUPAC Name | N-[(4-acetamidophenyl)carbamothioyl]-4-tert-butylbenzamide |
| Solubility | DMSO 74 mg/mL (200.28 mM) Water Insoluble Ethanol Insoluble |
| Appearance | White Crystal Powder |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Nihal M, Ahmad N, Wood GS. SIRT1 is upregulated in cutaneous T-cell lymphoma, and its inhibition induces growth arrest and apoptosis. Cell Cycle. 2014 Feb 15;13(4):632-40. PMID: 24343700.
Lain S, Hollick JJ, Campbell J, et al. Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. Cancer Cell. 2008 May;13(5):454-63. PMID: 18455128.