LKT Labs

Biochemicals for Life Science Research

Sterigmatocystin

Sterigmatocystin

Product ID S7717
Cas No. 10048-13-2
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $64.70 In stock
5 mg $243.70 In stock
10 mg $439.40 In stock
Bulk Quote

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Description

Sterigmatocystin is a mutagenic and carcinogenic mycotoxin initially produced by species of Aspergillus. Sterigmatocystin is a precursor of aflatoxin B1. In vitro, this compound activates ATM, p53, and Chk2 and damages DNA, inducing G2 phase cell cycle arrest; this mechanism may also involve PI3K/Akt/mTOR signaling. In vivo, chronic administration of sterigmatocystin decreases levels of glutathione, ascorbic acid, and α-tocopherol and increases levels of ROS, increasing lipid peroxidation.

Product Info

Cas No.

10048-13-2
Purity

≥98%
Formula

C18H12O6
Formula Wt.

324.28
Melting Point

240-246°C
Solubility

DMSO, Methanol, Ethanol, Acetone.

Appearance

Light Yellow needles

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

S7717 MSDS PDF
Info Sheet

S7717 Info Sheet PDF

References

Zhang D, Cui Y, Shen H, et al. Sterigmatocystin-induced DNA damage triggers G2 arrest via an ATM/p53-related pathway in human gastric epithelium GES-1 cells in vitro. PLoS One. 2013 May 21;8(5):e65044. PMID: 23705030.

Xing X, Wang J, Xing LX, et al. Involvement of MAPK and PI3K signaling pathway in sterigmatocystin-induced G2 phase arrest in human gastric epithelium cells. Mol Nutr Food Res. 2011 May;55(5):749-60. PMID: 21287681.

Delgado-Virgen F, Guzman-de-Peña D. Mechanism of Sterigmatocystin Biosynthesis Regulation by pH in Aspergillus nidulans. Braz J Microbiol. 2009 Oct;40(4):933-42. PMID: 24031444.

Sivakumar V, Thanislass J, Niranjali S, et al. Lipid peroxidation as a possible secondary mechanism of sterigmatocystin toxicity. Hum Exp Toxicol. 2001 Aug;20(8):398-403. PMID: 11727790.

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