LKT Labs

Biochemicals for Life Science Research

Spinorphin, cow

Spinorphin, cow

Product ID S6134
Cas No. 137201-62-8
Purity ≥95%
Product Unit SizeCostQuantityStock
5 mg $179.60 In stock
10 mg $299.30 In stock
25 mg $598.50 Please Inquire
Bulk Quote

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Description

Spinorphin is a heptapeptide with the sequence L-V-V-Y-P-W-T. Spinorphin is an endogenous enkephalinase inhibitor, antagonizing enzymes such as aminopeptidase IV, neutral endopeptidase, dipeptidyl peptidase III (DPP3), and angiotensin-converting enzyme (ACE); it also acts as an antagonist at the P2X3 receptor. Spinorphin exhibits antinociceptive, antidepressant, gastrointestinal motility modulating, anti-inflammatory, and immunomodulatory activities. Spinorphin also acts as an antagonist at N-formylpeptide receptors, preventing binding of chemotactic f-MLF to its receptor on polymorphonuclear (PMN) neutrophils and inhibiting neutrophil functionality.

Product Info

Cas No.

137201-62-8
Purity

≥95%
Formula

C45H64N8O10
Formula Wt.

877.06
IUPAC Name

(2S,3R)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylpentanoyl]amino]-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-hydroxybutanoic acid
Solubility

Soluble in water (1 mg/mL).
Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

S6134 MSDS PDF
Info Sheet

S6134 Info Sheet PDF

References

Thanawala V, Kadam VJ, Ghosh R. Enkephalinase inhibitors: potential agents for the management of pain. Curr Drug Targets. 2008 Oct;9(10):887-94. PMID: 18855623.

Jung KY, Moon HD, Lee GE, et al. Structure-activity relationship studies of spinorphin as a potent and selective human P2X(3) receptor antagonist. J Med Chem. 2007 Sep 6;50(18):4543-7. PMID: 17676725.

Yamamoto Y, Ono H, Ueda A, et al. Spinorphin as an endogenous inhibitor of enkephalin-degrading enzymes: roles in pain and inflammation. Curr Protein Pept Sci. 2002 Dec;3(6):587-99. PMID: 12470213.

Liang TS, Gao JL, Fatemi O, et al. The endogenous opioid spinorphin blocks fMet-Leu-Phe-induced neutrophil chemotaxis by acting as a specific antagonist at the N-formylpeptide receptor subtype FPR. J Immunol. 2001 Dec 1;167(11):6609-14. PMID: 11714831.

Nishimura K, Hazato T. Isolation and identification of an endogenous inhibitor of enkephalin-degrading enzymes from bovine spinal cord. Biochem Biophys Res Commun. 1993 Jul 30;194(2):713-9. PMID: 8343155.

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