LKT Labs

Biochemicals for Life Science Research

Sertraline Hydrochloride

Sertraline Hydrochloride

Product ID S1971
Cas No. 79559-97-0
Purity ≥98%
Product Unit SizeCostQuantityStock
500 mg $72.30 In stock
1 g $103.40 In stock
5 g $382.40 In stock
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Description

Sertraline exhibits antidepressant and anxiolytic activities; it is a typical selective serotonin reuptake inhibitor (SSRI). Sertraline primarily inhibits the 5-HT transporter (SERT), but also inhibits the dopamine transporter (DAT), α1-adrenergic receptors, and potentially σ1 receptors. Additionally, sertraline inhibits osteoclast formation and resorption and induces apoptosis in both osteoclasts and osteoblasts. This compound also acts as a functional inhibitor of acid sphingomyelinase (FIASMA).

Product Info

Cas No.

79559-97-0
Purity

≥98%
Formula

C17H17Cl2N • HCl
Formula Wt.

342.70
Chemical Name

(1S-cis)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine hydrochloride
IUPAC Name

(1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3, 4-tetrahydronaphthalen-1-amine;hydrochloride
Synonym

Lustral, Zoloft
Melting Point

243-245°C
Solubility

Slightly soluble in water and isopropyl alcohol. Sparingly soluble in ethanol.
Appearance

A White to Off-White Crystalline Powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

S1971 MSDS PDF
Info Sheet

S1971 Info Sheet PDF

References

Guaiana G, Gupta S, Chiodo D, et al. Agomelatine versus other antidepressive agents for major depression. Cochrane Database Syst Rev. 2013 Dec 17;12:CD008851. PMID: 24343836.

Zhu H, Bogdanov MB, Boyle SH, et al. Pharmacometabolomics of response to sertraline and to placebo in major depressive disorder - possible role for methoxyindole pathway. PLoS One. 2013 Jul 17;8(7):e68283. PMID: 23874572.

Hodge JM, Wang Y, Berk M, et al. Selective serotonin reuptake inhibitors inhibit human osteoclast and osteoblast formation and function. Biol Psychiatry. 2013 Jul 1;74(1):32-9. PMID: 23260229.

Meyer JH, Wilson AA, Sagrati S, et al. Serotonin transporter occupancy of five selective serotonin reuptake inhibitors at different doses: an [11C]DASB positron emission tomography study. Am J Psychiatry. 2004 May;161(5):826-35. PMID: 15121647.

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