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S-(N-Methylsulfinylbutylthiocarbamoyl)-glutathione is a conjugate of sulforaphane and glutathione. In vivo, sulforaphane conjugates with glutathione during metabolism. In animal models of prostate cancer, this conjugate displays antioxidative and anticancer chemotherapeutic activities, increasing levels of heme oxygenase 1 (HO-1), Nrf2, activated caspase 3, cleaved PARP, and Bax, decreasing levels of Keap1, Bcl-xl, 4E-BP1, mTOR, and cyclin D1, and slowing tumor growth.
| Cas No. | 289711-21-3 |
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| Purity | ≥98% |
| Formula | C16H28N4O7S3 |
| Formula Wt. | 484.61 |
| Chemical Name | S-(N-Methylsulfinylbutylthiocarbamoyl)-glutathione |
| IUPAC Name | L-γ-Glutamyl-S-{[4-(methylsulfinyl)butyl]carbamothioyl}-L-cysteinylglycine |
| Synonym | Sulforaphane glutathione conjugate |
| Solubility | Water |
| Appearance | White to off white powder |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
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| Brochures |
Keum YS, Khor TO, Lin W, et al. Pharmacokinetics and pharmacodynamics of broccoli sprouts on the suppression of prostate cancer in transgenic adenocarcinoma of mouse prostate (TRAMP) mice: implication of induction of Nrf2, HO-1 and apoptosis and the suppression of Akt-dependent kinase pathway. Pharm Res. 2009 Oct;26(10):2324-31. PMID: 19669099.