Description
Rebaudioside A is a steviol glycoside found in stevia leaves and used as a high-potency sucrose substitute. Rebaudioside A has been found to stimulate the release of gut peptides and enhance enteroendocrine cell differentiation in mouse small intestine organoids. Experimental determination showed that long-term treatment of C57BL6/J mice with rebaudioside A did not increase weight gain, alter insulin action, or disrupt circadian rhythms. Furthermore, chemically induced epilepsy in rats showed a dose-dependent decrease in spiking in epileptiform activity in the rats treated with rebaudioside A.