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This compound is a methoxy derivative of parent compound P7C3, an aminopropyl carbazole that exhibits antidepressant and neuroprotective activities. In animal models of chronic social defeat stress, P7C3 increases survival of dentate gyrus neurons. P7C3 also inhibits MPTP-induced neuronal death in animal models of Parkinson’s disease and delays the onset and preserves motor function in animal models of amyotrophic lateral sclerosis (ALS).
| Cas No. | 1325481-43-2 |
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| Purity | ≥98% |
| Formula | C22H20Br2N2O2 |
| Formula Wt. | 504.21 |
| Synonym | O-methoxy-P7C3, P7C3-OMe |
| Solubility | DMSO: ≥ 33 mg/mL |
| Appearance | White to off white powder |
| Store Temp | 4°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Walker AK, Rivera PD, Wang Q, et al. The P7C3 class of neuroprotective compounds exerts antidepressant efficacy in mice by increasing hippocampal neurogenesis. Mol Psychiatry. 2014 Apr 22. [Epub ahead of print]. PMID: 24751964.
De Jesús-Cortés H, Xu P, Drawbridge J, et al. Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of Parkinson disease. Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):17010-5. PMID: 23027934.
Tesla R, Wolf HP, Xu P, et al. Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):17016-21. PMID: 23027932.