LKT Labs

Biochemicals for Life Science Research

(R)-CR8

(R)-CR8

Product ID C6800
Cas No. 294646-77-8
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $104.10 Please Inquire
5 mg $312.20 Please Inquire
Bulk Quote

Quicklinks

Description

(R)-CR8 is an analog of roscovitine that inhibits cyclin-dependent kinases (CDKs) 1/2/3/5/7/9; it displays anticancer and neuroprotective activities. (R)-CR8 induces apoptosis and downregulates expression of Mcl-1 in neuroblastoma cells. In chromic myelogenous leukemia (CML) cells, (R)-CR8 inhibits cell cycle progression. In animal models of spinal cord injury, this compound decreases neurodegeneration, cognitive decline, and microglial activation. CR8 also decreases sensorimotor deficits, cognitive deficits, and lesion volume by limiting cell cycle activation in animal models of traumatic brain injury.

Product Info

Cas No.

294646-77-8
Purity

≥98%
Formula

C24H29N7O
Formula Wt.

431.54
Chemical Name

2-(R)-(1-Ethyl-2-hydroxyethylamino)-6-(4-(2-pyridyl)benzyl)-9-isopropylpurine
IUPAC Name

(2R)-2-[(9-Isopropyl-6-{[4-(2-pyridinyl)benzyl]amino}-9H-purin-2-yl)amino]-1-butanol
Solubility

Soluble in DMSO or 100% ethanol
Appearance

White to off-white solid

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

C6800 MSDS PDF
Info Sheet

C6800 Info Sheet PDF

References

Troadec S, Blairvacq M, Oumata N, et al. Antitumoral effects of cyclin-dependent kinases inhibitors CR8 and MR4 on chronic myeloid leukemia cell lines. J Biomed Sci. 2015 Jul 17;22:57. PMID: 26184865.

Wu J, Zhao Z, Sabirzhanov B, et al. Spinal cord injury causes brain inflammation associated with cognitive and affective changes: role of cell cycle pathways. J Neurosci. 2014 Aug 13;34(33):10989-1006. PMID: 25122899.

Kabadi SV, Stoica BA, Loane DJ, et al. CR8, a novel inhibitor of CDK, limits microglial activation, astrocytosis, neuronal loss, and neurologic dysfunction after experimental traumatic brain injury. J Cereb Blood Flow Metab. 2014 Mar;34(3):502-13. PMID: 24398934.

Bettayeb K, Baunbæk D, Delehouze C, et al. CDK Inhibitors Roscovitine and CR8 Trigger Mcl-1 Down-Regulation and Apoptotic Cell Death in Neuroblastoma Cells. Genes Cancer. 2010 Apr;1(4):369-80. PMID: 21779453.

Bettayeb K, Oumata N, Echalier A, et al. CR8, a potent and selective, roscovitine-derived inhibitor of cyclin-dependent kinases. Oncogene. 2008 Oct 2;27(44):5797-807. PMID: 18574471.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • B9200

    BX-795

    PDK1 inhibitor.
    ≥98%
  • T0094

    2′,7-Bisacetyltaxol

    Taxane synthesis intermediate.
    ≥98%
  • B7118

    Brevetoxin 3 42-carboxylic Acid

    Brevetoxins are lipid-soluble polyether neurotoxin...
    ≥95%
  • T3037

    Thienylmethyl Isothiocyanate

    Thienylbutyl ITC analog.
    ≥98%
  • D0363

    Daptomycin

    Anionic lipopeptide, alters cell membrane organiza...
    ≥90%
  • P1770

    Perillyl Alcohol

    Terpene found in various plant and fruit sources; ...
    ≥85%
  • P0110

    (R)-P7C3-OMe

    Methoxy aminopropyl carbazole, neuroprotective.
    ≥98%
  • L1785

    Levofloxacin Hemihydrate

    Fluoroquinolone, S-(-) isomer of ofloxacin; topois...
    ≥98%
  • AS109

    Soy Isoflavone Standards Kit

    Soy Isoflavone Standards Kit Contents: -Column: Co...
  • M0275

    Mastoparan 17

    Peptide, inactive mastoparan analog used to measur...
    ≥95%
  • K1679

    (+)-Ketanserin Tartrate

    5-HT2A and TRPV1 antagonist, potential α1-adrener...
    ≥98%
  • X1753

    Xenopsin

    Peptide hormone, neurotensin analog found in amphi...
    ≥95%
  • U6959

    Urotensin II, human

    Endogenous peptide, involved in stress signaling; ...
    ≥95%
  • H3274

    HIV p17 Gag (77-85)

    Immunodominant HIV Gag epitope.
    ≥98%
  • K5200

    KN-93

    CamKII inhibitor and potential L-type Ca2+ channel...
    ≥98%
  • E7433

    Etidronate Disodium

    Bisphosphonate, chelating agent.
    ≥98%
  • P014442

    Palbociclib

    CDK4/6 inhibitor.
    ≥98%
  • V3355

    Vindoline

    Semi-synthetic vinca alkaloid found in Catharanthu...
    ≥98%
  • V3213

    Vidarabine Monophosphate

    Nucleoside (adenosine) analog found in Tethyra cry...
    ≥98.0%
  • A0968

    Adrenocorticotropic Hormone (1-24), human

    Endogenous peptide hormone fragment, involved in s...
    ≥95%