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Quinacrine exhibits anti-parasitic, anti-protozoan, anticancer, and anti-inflammatory activities. Quinacrine alters cell membrane permeability and is clinically used to treat infections of Giardia. In colon cancer cells, quinacrine induces apoptosis, activates p53 and p21, and inhibits topoisomerase. In other cellular models, quinacrine decreases TNF-α, IL-1β, and CCL21 production, suppresses migration of dendritic cells, and inhibits activation of CD8+ T cells. TEST!!!!!!
| Cas No. | 6151-30-0 |
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| Purity | ≥97% |
| Formula | C23H30ClN3O • 2HCl • 2H2O |
| Formula Wt. | 508.92 |
| Chemical Name | N4-(6-Chloro-2-methoxy-9-acridinyl)-N1,N1-diethyl-1,-4-pentanediamine dihydrochloride dihydrate |
| IUPAC Name | 4-N-(6-chloro-2-methoxyacridin-9-yl)-1-N,1-N-diethylpentane-1, 4-diamine;dihydrate;dihydrochloride |
| Synonym | Atebrine hydrochloride, RP-866, SN-390, Mepacrine |
| Melting Point | 248-250°C(dec) |
| Solubility | Soluble in hot water. Slightly soluble in ethanol, methanol or water. Insoluble in ether, benzene or acetone. |
| Appearance | Bright yellow powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Mohapatra P, Preet R, Das D, et al. Quinacrine-mediated autophagy and apoptosis in colon cancer cells is through a p53- and p21-dependent mechanism. Oncol Res. 2012;20(2-3):81-91. PMID: 23193914.
Gorbachev AV, Gasparian AV, Gurova KV, et al. Quinacrine inhibits the epidermal dendritic cell migration initiating T cell-mediated skin inflammation. Eur J Immunol. 2007 Aug;37(8):2257-67. PMID: 17634953.
Fasanmade AA, Owuor ED, Ee RP, et al. Quinacrine induces cytochrome c-dependent apoptotic signaling in human cervical carcinoma cells. Arch Pharm Res. 2001 Apr;24(2):126-35. PMID: 11339632.