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Psoralen is a furanocoumarin compound originally found in Psoralea coryfolia that exhibits anti-angiogenic activity. Psoralen is currently used to treat psoriasis with the additional of UVA light. Psoralen inhibits angiogenesis and induces G0/G1 phase cell cycle arrest and apoptosis in endothelial cells. This compound also inhibits topoisomerase I and induces DNA interstrand crosslinks and monoadducts, displaying carcinogenic potential as well.
| Cas No. | 66-97-7 |
|---|---|
| Purity | ≥98% |
| Formula | C11H6O3 |
| Formula Wt. | 186.16 |
| IUPAC Name | furo[3,2-g]chromen-7-one |
| Synonym | Ficusin |
| Melting Point | 163-164°C |
| Solubility | Soluble in ethanol (10 mg/ml), ethyl acetate, acetone, and water (1.93 mg/ml at 25 °C). |
| Appearance | White Crystal Powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Chopra B, Dhingra AK, Dhar KL. Psoralea corylifolia L. (Buguchi) - folklore to modern evidence: review. Fitoterapia. 2013 Oct;90:44-56. PMID: 23831482.
Diwan R, Malpathak N. Furanocoumarins: novel topoisomerase I inhibitors from Ruta graveolens L. Bioorg Med Chem. 2009 Oct 1;17(19):7052-5. PMID: 19736019.
Derheimer FA, Hicks JK, Paulsen MT, et al. Psoralen-induced DNA interstrand cross-links block transcription and induce p53 in an ataxia-telangiectasia and rad3-related-dependent manner. Mol Pharmacol. 2009 Mar;75(3):599-607. PMID: 19064630.
Deng H, Yan CL, Hu Y, et al. Photochemotherapy inhibits angiogenesis and induces apoptosis of endothelial cells in vitro. Photodermatol Photoimmunol Photomed. 2004 Aug;20(4):191-9. PMID: 15238097.