LKT Labs

Biochemicals for Life Science Research

Pregnenolone

Pregnenolone

Product ID P7023
Cas No. 145-13-1
Purity ≥98%
Product Unit SizeCostQuantityStock
100 g $330.80 In stock
25 g $121.30 In stock
5 g $44.10 In stock
Bulk Quote

Quicklinks

Description

Pregnenolone is the endogenous precursor to all steroid hormones; it exhibits neuromodulatory, cognition enhancing, and antipsychotic activities. Pregnenolone decreases the negative symptoms of schizophrenia and increases attention and working memory performance in schizophrenic subjects. Pregnenolone sulfate acts as a positive allosteric NMDA receptor potentiator and a negative allosteric GABA-A receptor potentiator. Additionally, pregnenolone sulfate activates transient receptor potential melanostatin (TRPM3) channels, increasing Ca2+ influx and insulin secretion in islet cells.

Product Info

Cas No.

145-13-1
Purity

≥98%
Formula

C21H32O2
Formula Wt.

316.48
Chemical Name

(3β)-3-Hydroxypregn-5-en-20-one
IUPAC Name

1-[(3S,8S,9S,10R,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,11, 12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone
Melting Point

193°C
Solubility

Sparingly soluble in water. Soluble in ethyl acetate (1:1), acetone (0.006g/mL) and ethanol (.010g/mL).
Appearance

White Crystal Powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

P7023 MSDS PDF
Info Sheet

P7023 Info Sheet PDF
Brochures

TRP Channel Modulator Flyer

References

Kostakis E, Smith C, Jang MK, et al. The neuroactive steroid pregnenolone sulfate stimulates trafficking of functional N-methyl D-aspartate receptors to the cell surface via a noncanonical, G protein, and Ca2+-dependent mechanism. Mol Pharmacol. 2013 Aug;84(2):261-74. PMID: 23716622.

Marx CE, Bradford DW, Hamer RM, et al. Pregnenolone as a novel therapeutic candidate in schizophrenia: emerging preclinical and clinical evidence. Neuroscience. 2011 Sep 15;191:78-90. PMID: 21756978.

Wagner TF, Loch S, Lambert S, et al. Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic beta cells. Nat Cell Biol. 2008 Dec;10(12):1421-30. PMID: 18978782.

Majewska MD, Mienville JM, Vicini S. Neurosteroid pregnenolone sulfate antagonizes electrophysiological responses to GABA in neurons. Neurosci Lett. 1988 Aug 1;90(3):279-84. PMID: 3138576.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • Z0146

    Z-Ala-Ala-Leu-pNA

    Proteinase subtrate.
    ≥95%
  • A5072

    Amsacrine

    Acridine derivative, DNA intercalator; topoisomera...
    ≥98%
  • B7058

    Brompheniramine Maleate

    Pheniramine derivative; histamine H1 and mAChR ant...
    ≥98%
  • S0044

    Salbutamol Free Base

    β2-adrenergic agonist.
    ≥98%
  • E5358

    Enoxacin

    Fluoroquinolone; vacuolar H+ ATPase, topoisomerase...
    ≥98%
  • R3586

    Rivastigmine Tartrate

    AChE and BChE inhibitor.
    ≥99%
  • A3212

    3′-Azido-3′-deoxythymidine

    Nucleoside (thymidine) analog; DNA chain terminato...
    ≥98%
  • C6956

    Crotamiton

    Antipruritic.
    ≥98%
  • C5773

    Cortistatin-14

    Endogenous neuropeptide, somatostatin analog; soma...
    ≥95%
  • A6971

    ARRY-162

    MEK1/2 and ERK inhibitor.
    ≥99%
  • G1975

    Gestrinone

    Synthetic steroid hormone; AR agonist, ER and PR a...
    ≥98%
  • S6233

    Spiramycin Hexanedioate

    Macrolide; protein synthesis inhibitor.
    ≥90%
  • O4672

    Olsalazine Sodium

    5-Aminosalicylate prodrug, NSAID; COX-1/2 inhibito...
    ≥98%
  • L0249

    Laminin Peptide YIGSR-NH2

    Laminin-derived peptapeptide.
    ≥98%
  • A044176

    Abemaciclib

    CDK inhibitor.
    ≥98%
  • C822706

    Curvularin

    Macrocyclic lactone.
    ≥98%
  • G1310

    GDC-0349

    mTOR inhibitor.
    ≥98%
  • D1849

    4′-Demethylepipodophyllotoxin

    Podophyllotoxin derivative found in Podophyllum; t...
    ≥98%
  • A4646

    ALLN

    Calpain I/II inhibitor.
    ≥98%
  • P9770

    Pyrrolostatin

    Antioxidant.
    ≥98%