LKT Labs

Biochemicals for Life Science Research

PP-242

PP-242

Product ID P6004
Cas No. 1092351-67-1
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $63.90 Please Inquire
5 mg $105.40 In stock
10 mg $154.90 Please Inquire
25 mg $353.10 Please Inquire
Bulk Quote

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Description

PP-242 is an inhibitor of mTORC1/2 that displays anticancer chemotherapeutic and anti-metastatic activities. In various cellular models of acute leukemia, PP-242 inhibits cell proliferation. In animal models of pheochromocytoma, PP-242 induces apoptosis, upregulates expression of Bax, downregulates expression of Bcl-2, and decreases tumor volume. In gastric cancer cells, this compound also inhibits cell proliferation, migration, and invasion and suppresses tube formation and vascular invasion.

Product Info

Cas No.

1092351-67-1
Purity

≥98%
Formula

C16H16N6O
Formula Wt.

308.34
IUPAC Name

2-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-1H-indol-5-ol
Synonym

Pp242, PP242, PP 242, Torkinib
Solubility

DMSO 61 mg/mL (197.83 mM) Ethanol 18 mg/mL (58.37 mM) Water Insoluble
Appearance

Tan to off white powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

P6004 MSDS PDF
Info Sheet

P6004 Info Sheet PDF

References

Shi F, Yang X, Gong Y, et al. The antileukemia roles of PP242 alone or in combination with daunorubicin in acute leukemia. Anticancer Drugs. 2015 Apr;26(4):410-21. PMID: 25535978.

Zhang X, Wang X, Qin L, et al. The dual mTORC1 and mTORC2 inhibitor PP242 shows strong antitumor activity in a pheochromocytoma PC12 cell tumor model. Urology. 2015 Jan;85(1):273.e1-7. PMID: 25440763.

Xing X, Zhang L, Wen X, et al. PP242 suppresses cell proliferation, metastasis, and angiogenesis of gastric cancer through inhibition of the PI3K/AKT/mTOR pathway. Anticancer Drugs. 2014 Nov;25(10):1129-40. PMID: 25035961.

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