LKT Labs

Biochemicals for Life Science Research

PP-1

PP-1

Product ID P6232
Cas No. 172889-26-8
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $71.70 In stock
5 mg $110.30 In stock
25 mg $328.50 In stock
Bulk Quote

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Description

PP-1 inhibits members of the Src kinase family and displays antioxidative, anti-inflammatory, and anti-arrhythmic characteristics. In an in vitro model of oxidative stress, PP-1 inhibits hydrogen peroxide-induced production of macrophage migration inhibitory factor (MIF). PP-1 decreases total and phosphorylated levels of Src and increases connexin-43 levels and gap junction communication. Additionally, PP-1 decreases ventricular tachycardia and sudden death in animal models of arrhythmia.

Product Info

Cas No.

172889-26-8
Purity

≥98%
Formula

C16H19N5
Formula Wt.

281.36
Chemical Name

4-Amino-1-tert-butyl-3-(4-methylphenyl)pyrazolo[3,4-d]pyrimidine
IUPAC Name

1-tert-butyl-3-(4-methylphenyl)pyrazolo[3,4-d]pyrimidin-4-amine
Solubility

DMSO (25mg/ml), slightly soluble in ethanol
Appearance

White to off white powder

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

P6232 MSDS PDF
Info Sheet

P6232 Info Sheet PDF

References

Rao F, Deng CY, Zhang QH, et al. Involvement of Src tyrosine kinase and protein kinase C in the expression of macrophage migration inhibitory factor induced by H2O2 in HL-1 mouse cardiac muscle cells. Braz J Med Biol Res. 2013 Sep;46(9):746-51. PMID: 24036910.

Sovari AA, Iravanian S, Dolmatova E, et al. Inhibition of c-Src tyrosine kinase prevents angiotensin II-mediated connexin-43 remodeling and sudden cardiac death. J Am Coll Cardiol. 2011 Nov 22;58(22):2332-9. PMID: 22093512.

Wijetunge S, Hughes AD. Src family tyrosine kinases mediate contraction of rat isolated tail arteries in response to a hyposmotic stimulus. J Hypertens. 2007 Sep;25(9):1871-8. PMID: 17762651.

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