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Phomopsin A is a cyclic hexapeptide isolated from Phomopsis leptostromiformis. It is an antibiotic and a modifier of tubulin functions. It is a very potent inhibitor of microtubule assembly by binding to tubulin at a site different from the colchicine binding site. It has anti-proliferative activity against MCF-7 cells
TEST!!!!!!
| Cas No. | 64925-80-0 |
|---|---|
| Purity | ≥98% |
| Formula | C36H45ClN6O12 |
| Formula Wt. | 789.24 |
| Chemical Name | Phomopsin A |
| IUPAC Name | (E)-2-[[(E)-2-[[(2S)-1-[(2S,3S,6S,9S,10R)-14-chloro-10-ethyl-2,13-dihydroxy-10-methyl-3-(methylamino)-4,7-dioxo-6-prop-1-en-2-yl-11-oxa-5,8-diazabicyclo[10.3.1]hexadeca-1(16),12,14-triene-9-carbonyl]-2,5-dihydropyrrole-2-carbonyl]amino]-3-methylpent-2-enoyl]amino]but-2-enedioic acid |
| Synonym | Phomopsin; AC1O5PXJ; PHO-A; NSC 381839 |
| Appearance | White powder |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Hamel E. Natural products which interact with tubulin in the vinca
domain: maytansine, rhizoxin, phomopsin A, dolastatins 10 and
15 and halichondrin B. Pharmacol Ther. 1992;55(1):31-51. PMID: 1287674
Li Y , Kobayashi H, Tokiwa Y, et al. Interaction of phomopsin A with porcine brain tubulin. Inhibition of tubulin polymerization and binding at a rhizoxin binding site. Biochem Pharmacol. 1992, 43(2):219-24. PMID: 1739410
van Aswegen CH, Lewko WM, Wittliff JL. Influence of phomopsin and ivalin on steroid-hormone binding and growth of MCF-7 human breast cancer cells. J Toxicol Environ Health. 1985;16(1):13-23. PMID: 4068051