LKT Labs

Biochemicals for Life Science Research

Phellodendrine

Phellodendrine

Product ID P3018
Cas No. 6873-13-8
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $66.90 In stock
5 mg $267.50 In stock
Bulk Quote

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Description

Phellodendrine is a quaternary base alkaloid found in the bark of Phellodendron. Phellodendrine exhibits immunosuppressive and anti-inflammatory activities. Phellodendrine inhibits local semisyngenic and allogenic graft-versus-host (GVH) reactions and suppresses the induction of delayed-type hypersensitivity reactions without affecting the overall antibody response in animal models. Additionally, phellodendrine decreases urinary protein, plasma creatine, and plasma cholesterol levels in animal models of crescentic-type antiGBM nephritis, inhibiting crescent formation, adhesion, and fibrinoid necrosis in glomeruli; this compound also prevents nephritis-induced increases in immune cells and cytokines.

Product Info

Cas No.

6873-13-8
Purity

≥98%
Formula

C20H24NO4
Formula Wt.

342.41
IUPAC Name

(7S,13aS)-3,10-dimethoxy-7-methyl-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinolin-7-ium-2,11-diol
Solubility

Soluble in Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone
Appearance

White to off white powder

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

P3018 MSDS PDF
Info Sheet

P3018 Info Sheet PDF

References

Mori H, Fuchigami M, Inoue N, et al. Principle of the bark of Phellodendron amurense to suppress the cellular immune response: effect of phellodendrine on cellular and humoral immune responses. Planta Med. 1995 Feb;61(1):45-9. PMID: 7700991.

Hattori T, Furuta K, Hayashi K, et al. Studies on the antinephritic effects of plant components (6): antinephritic effects and mechanisms of phellodendrine (OB-5) on crescentic-type anti-GBM nephritis in rats (2). Jpn J Pharmacol. 1992 Nov;60(3):187-95. PMID: 1491511.

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