LKT Labs

Biochemicals for Life Science Research

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Penitrem A

Product ID P1952
Cas No. 12627-35-9
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $82.70 In stock
5 mg $396.80 In stock
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Description

Penitrem A is a neuroactive mycotoxin initially produced by species of Penicillum. Penitrem A exhibits tremorgenic activity. In vitro and in vivo, penitrem A inhibits Ca2+/voltage-sensitive K+ (BK) channels. Penitrem A also potentiates GABA-A receptor function in the forebrain and inhibits uptake of GABA and glutamate into synaptosomes. Additionally, penitrem A may disrupt learning acquisition but not memory or task performance in animal models examining passive avoidance testing. TEST!!!!!!

Product Info

Cas No.

12627-35-9
Purity

≥98%
Formula

C37H44ClNO6
Formula Wt.

634.20
Synonym

Tremortin A
Melting Point

224-230°C(dec)

Solubility

Acetone, Methanol, and DMSO.

Appearance

White Powder

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

P1952 MSDS PDF
Info Sheet

P1952 Info Sheet PDF

References

Moldes-Anaya A, Rundberget T, Fæste CK, et al. Neurotoxicity of Penicillium crustosum secondary metabolites: tremorgenic activity of orally administered penitrem A and thomitrem A and E in mice. Toxicon. 2012 Dec 15;60(8):1428-35. PMID: 23085423.

Asano S, Bratz IN, Berwick ZC, et al. Penitrem A as a tool for understanding the role of large conductance Ca(2+)/voltage-sensitive K(+) channels in vascular function. J Pharmacol Exp Ther. 2012 Aug;342(2):453-60. PMID: 22580348.

Moldes-Anaya AS, Fonnum F, Eriksen GS, et al. In vitro neuropharmacological evaluation of penitrem-induced tremorgenic syndromes: importance of the GABAergic system. Neurochem Int. 2011 Dec;59(7):1074-81. PMID: 21924313.

Deschaux O, Bizot JC. Effects of penitrem A on rat's performances in passive avoidance and Morris water maze tests. Mycopathologia. 1997;138(2):99-104. PMID: 9433810.

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