LKT Labs

Biochemicals for Life Science Research

Panaxatriol

Panaxatriol

Product ID P0254
Cas No. 32791-84-7
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $201.80 In stock
10 mg $350.50 In stock
25 mg $700.60 In stock
Bulk Quote

Quicklinks

Description

Panaxatriol is a triterpene sapogenin originally found in species of Panax (ginseng) that exhibits anti-inflammatory, hepatoprotective, anti-arrhythmic, and antioxidative activities. Panaxatriol increases expression of heme oxygenase 1 (HO-1) and activation of Nrf2 signaling in neurons in a PI3K/Akt-dependent manner. Panaxatriol also decreases acetaminophen-induced increases in ALT and TNF-α, preventing liver injury in vivo. Additionally, panaxatriol inhibits Ca2+ channels, decreasing channel open time and open state probability in vitro and displaying anti-arrhythmic potential.

Product Info

Cas No.

32791-84-7
Purity

≥98%
Formula

C30H52O4
Formula Wt.

476.73
IUPAC Name

(3S,5R,6R,8R,9R,10R,12R,13R,14R,17S)-4,4,8,10,14-pentamethyl-17-[(2R)-2, 6,6-trimethyloxan-2-yl]-2,3,5,6,7,9,11,12,13,15,16, 17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,6,12-triol
Melting Point

238-239C
Solubility

Soluble in DMSO.
Appearance

White Powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

P0254 MSDS PDF
Info Sheet

P0254 Info Sheet PDF

References

Huang Y, Yu J, Wan F, et al. Panaxatriol Saponins Attenuated Oxygen-Glucose Deprivation Injury in PC12 Cells via Activation of PI3K/Akt and Nrf2 Signaling Pathway. Oxid Med Cell Longev. 2014;2014:978034. PMID: 24955212.

Wang S, Wang X, Luo F, et al. Panaxatriol saponin ameliorated liver injury by acetaminophen via restoring thioredoxin-1 and pro-caspase-12. Liver Int. 2013 Sep 11. [Epub ahead of print]. PMID: 24119161.

Zhang WJ, Zhong GG, Jiang Y, et al. Single channel analysis on calcium channel blockade action of panaxadiol and panaxatriol saponins on cultured rat ventricular myocytes. Zhongguo Yao Li Xue Bao. 1994 Mar;15(2):173-6. PMID: 7516611.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • P0055

    P55-TNFR Peptide

    Peptide fragment of P55 TNF receptor.
    ≥95%
  • B1955

    Benztropine Mesylate

    DAT inhibitor.
    ≥99%
  • A0823

    N-Acetyl-S-(N′-methylthiocarbamoyl)-L-cysteine

    Cysteine-ITC conjugate, antioxidant; aldehyde dehy...
    ≥98%
  • P5712

    Podophyllotoxin

    Non-alkaloid lignan found in Podophyllum,derivativ...
    ≥90%
  • D0353

    Danofloxacin Mesylate

    Fluoroquinolone; bacterial DNA gyrase inhibitor.
    ≥98%
  • P1202

    PD-325901

    MEK1/2 and Raf inhibitor.
    ≥98%
  • G2871

    Growth Hormone Releasing Factor, cow

    Endogenous peptide hormone, involved in growth hor...
    ≥95%
  • S5751

    Somatostatin-25

    Endogenous neuropeptide hormone; somatostatin agon...
    ≥95%
  • T0299

    Tazobactam Sodium

    β-lactamase inhibitor.
    ≥98%
  • M0803

    MC1568

    HDAC inhibitor. May reduce blood pressure in hyper...
    ≥98%
  • O6845

    Orlistat

    Fatty acid synthase inhibitor.
    ≥98%
  • W0273

    R-(+)-Warfarin >99

    Coumarin; VKORC1 inhibitor.
    ≥98%
  • D3429

    Dihydrocytochalasin B

    Mycotoxin derivative; actin polymerization inhibit...
    ≥98%
  • B8363

    Bupropion Hydrochloride

    α3β2, α3β4, α4β2 nAChR antagonist, indirect ...
    ≥98%
  • T7044

    Triamcinolone Acetonide Acetate

    Steroid; glucocorticoid agonist.
    ≥97%
  • O2144

    Ofloxacin

    Fluoroquinolone; topoisomerase IV and bacterial DN...
    ≥98%
  • I7455

    R-1-Isothiocyanato-7-(methylsulfinyl)-heptane

    ITC, antioxidant.
    ≥98%
  • D0368

    2-Epi-16-deoxysarcophine

    Cembranoid found in Sarcophyton.
    ≥98%
  • E537331

    Enniatin Complex

    Mycotoxin contaminant found in cereal grains.
    ≥98%
  • E5200

    Enalaprilat Dihydrate

    Enalapril metabolite; ACE inhibitor.
    ≥98%