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Oxolinic acid is a fluoroquinolone antibiotic that is used in plants and veterinary medicine; it’s antibacterial efficacy stems from inhibition of bacterial DNA gyrase. When combined with metals such as ruthenium, manganese, nickel, or zinc, the metal-oxolinic acid complex intercalates with DNA. Additionally, oxolinic acid may lower the threshold for induction of seizure through activation of excitatory amino acid receptors.
| Cas No. | 14698-29-4 |
|---|---|
| Purity | ≥98% |
| Formula | C13H11NO5 |
| Formula Wt. | 261.23 |
| IUPAC Name | 5-ethyl-8-oxo-[1,3]dioxolo[4,5-g]quinoline-7-carboxylic acid |
| Appearance | White Powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Kljun J, Bratsos I, Alessio E, et al. New uses for old drugs: attempts to convert quinolone antibacterials into potential anticancer agents containing ruthenium. Inorg Chem. 2013 Aug 5;52(15):9039-52. PMID: 23886077.
Tarushi A, Lafazanis K, Kljun J, et al. First- and second-generation quinolone antibacterial drugs interacting with zinc(II): structure and biological perspectives. J Inorg Biochem. 2013 Apr;121:53-65. PMID: 23353082.
Kwon HR, Choi GJ, Choi YH, et al. Suppression of pine wilt disease by an antibacterial agent, oxolinic acid. Pest Manag Sci. 2010 Jun;66(6):634-9. PMID: 20151406.
Williams PD, Helton DR. The proconvulsive activity of quinolone antibiotics in an animal model. Toxicol Lett. 1991 Sep;58(1):23-8. PMID: 1897004.