LKT Labs

Biochemicals for Life Science Research

NPS-2143 Hydrochloride

NPS-2143 Hydrochloride

Product ID N6272
Cas No. 324523-20-8
Purity ≥99%
Product Unit SizeCostQuantityStock
1 mg $71.70 In stock
5 mg $111.50 In stock
25 mg $413.50 In stock
Bulk Quote

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Description

NPS-2143 is an antagonist at Ca2+-sensing receptors. It displays anti-osteoporotic, neuroprotective, cardioprotective, and antihypertensive activities. This calcilytic increases bone turnover without decreasing bone mineral density. NPS-2143 also inhibits production of amyloid-β (Aβ) and VEGF and neuronal death in models of Alzheimer’s disease. This compound prevents development of pulmonary arterial hypertension (PAH) and right ventricular hypertrophy in vivo. Additionally, NPS-2143 decreases secretion of CCK, inhibits increases in intracellular Ca2+ levels, and increases secretion of parathyroid hormone (PTH).

Product Info

Cas No.

324523-20-8
Purity

≥99%
Formula

C24H25ClN2O2 • HCl
Formula Wt.

445.38
IUPAC Name

2-Chloro-6-[(2R)-2-hydroxy-3-{[2-methyl-1-(2-naphthyl)-2-propanyl]amino}propoxy]benzonitrile hydrochloride (1:1)
Synonym

SB-262470A Hydrochloride, NPS2143, NPS 2143
Solubility

Soluble in DMSO (100 mM), and ethanol (10 mM)
Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

N6272 MSDS PDF
Info Sheet

N6272 Info Sheet PDF

References

Dal Prà I, Chiarini A, Pacchiana R, et al. Calcium-Sensing Receptors of Human Astrocyte-Neuron Teams: Amyloid-β-Driven Mediators and Therapeutic Targets of Alzheimer's Disease. Curr Neuropharmacol. 2014 Jul;12(4):353-64. PMID: 25342943.

Dal Prà I, Armato U, Chioffi F, et al. The Aβ peptides-activated calcium-sensing receptor stimulates the production and secretion of vascular endothelial growth factor-A by normoxic adult human cortical astrocytes. Neuromolecular Med. 2014 Dec;16(4):645-57. PMID: 24948534.

Yamamura A. Pathological function of Ca2+-sensing receptor in pulmonary arterial hypertension. J Smooth Muscle Res. 2014;50:8-17. PMID: 24770445.

Nakajima S, Hira T, Hara H. Calcium-sensing receptor mediates dietary peptide-induced CCK secretion in enteroendocrine STC-1 cells. Mol Nutr Food Res. 2012 May;56(5):753-60. PMID: 22648622.

Nemeth EF, Delmar EG, Heaton WL, et al. Calcilytic compounds: potent and selective Ca2+ receptor antagonists that stimulate secretion of parathyroid hormone. J Pharmacol Exp Ther. 2001 Oct;299(1):323-31. PMID: 11561095.

Gowen M, Stroup GB, Dodds RA, et al. Antagonizing the parathyroid calcium receptor stimulates parathyroid hormone secretion and bone formation in osteopenic rats. J Clin Invest. 2000 Jun;105(11):1595-604. PMID: 10841518.

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