LKT Labs

Biochemicals for Life Science Research

Norfloxacin Nicotinate

Norfloxacin Nicotinate

Product ID N5769
Cas No. 118803-81-9
Purity ≥98%
Product Unit SizeCostQuantityStock
1 g $37.40 In stock
10 g $104.90 In stock
50 g $337.30 In stock
Bulk Quote

Quicklinks

Description

Norfloxacin is a first generation fluoroquinolone antibiotic that exhibits antibacterial, anti-inflammatory, and anticancer activities. Norfloxacin inhibits DNA gyrase and topoisomerase IV; it is clinically used to treat urinary tract infections and prostatitis. In neutrophils from cirrhotic subjects, norfloxacin increases expression of IL-10 and heme oxygenase 1 (HO-1) and decreases expression of pro-inflammatory cytokines. Additionally, when complexed with gold(III), norfloxacin binds DNA and inhibits cellular proliferation in several cancer cell lines.

Product Info

Cas No.

118803-81-9
Purity

≥98%
Formula

C16H18FN3O3 • C6H5NO2
Formula Wt.

442.44
IUPAC Name

1-ethyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid;pyridine-3-carboxylic acid
Melting Point

220-227°C
Solubility

Soluble in water.

Appearance

White/Slight Yellow Crystal Powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

N5769 MSDS PDF
Info Sheet

N5769 Info Sheet PDF

References

Gouvea LR, Garcia LS, Lachter DR, et al. Atypical fluoroquinolone gold(III) chelates as potential anticancer agents: relevance of DNA and protein interactions for their mechanism of action. Eur J Med Chem. 2012 Sep;55:67-73. PMID: 22835721.

Gómez-Hurtado I, Zapater P, Bellot P, et al. Interleukin-10-mediated heme oxygenase 1-induced underlying mechanism in inflammatory down-regulation by norfloxacin in cirrhosis. Hepatology. 2011 Mar;53(3):935-44. PMID: 21374664.

Padeĭskaia EN. Norfloxacin: more than 20 years of clinical use, the results and place among fluoroquinolones in modern chemotherapy for infections. Antibiot Khimioter. 2003;48(9):28-36. PMID: 15002177.

Drlica K, Zhao X. DNA gyrase, topoisomerase IV, and the 4-quinolones. Microbiol Mol Biol Rev. 1997 Sep;61(3):377-92. PMID: 9293187.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • G1975

    Gestrinone

    Synthetic steroid hormone; AR agonist, ER and PR a...
    ≥98%
  • W0270

    (±)-Warfarin Sodium Clathrate

    Coumarin; VKORC1 inhibitor.
    ≥98%
  • L0109

    Lactalbumin

    Found in milk and whey, cation and fatty acid chel...
    ≥80%
  • P1768

    Peptide YY (3-36), human

    Endogenous neuropeptide fragment, involved in ente...
    ≥95%
  • G3351

    Ginkgolic Acid (17:1)

    Mixture of alkylphenols found in Ginkgo; HIV prote...
    ≥98%
  • F1654

    Fenoldopam Mesylate

    Benzazepine derivative; D1 partial agonist, potent...
    ≥98%
  • D564088

    10-Acetyl Docetaxel

    10-Acetyl Docetaxel is an analog of the anti-cance...
    ≥98%
  • F4400

    Flag Peptide

    Peptide, used to tag proteins for affinity chromat...
    ≥95%
  • K3352

    Kinetensin

    Peptide, neurotensin analog.
    ≥95%
  • O6953

    Ornidazole

    5-Nitroimidazole derivative; genotoxic.
    ≥98%
  • R6871

    RR-SRC

    Src-derived tyrosine kinase substrate.
    ≥95%
  • O4672

    Olsalazine Sodium

    5-Aminosalicylate prodrug, NSAID; COX-1/2 inhibito...
    ≥98%
  • C6132

    CPI-203

    Triazolothienodiazepine, JQ-1 derivative; BRD inhi...
    ≥99%
  • A0534

    Abiraterone

    Progesterone derivative; Cyp17A1 inhibitor.
    ≥99%
  • A0916

    Acepromazine Maleate

    Phenothiazine derivative; D1/2 and 5-HT1A/2A antag...
    ≥98%
  • AS104

    Camptothecins Standards Kit

    Camptothecins Standards Kit Contents: -Column: Cos...
  • L0077

    Latrunculin B

    Latrunculin B is a thiazolidinone macrolide found ...
  • T3097

    Thymosin α-1 Acetate

    Endogenous peptide, involved in hormone regulation...
    ≥95%
  • T2817

    Theophylline

    Methylxanthine; PDE inhibitor, A1/2 adenosine anta...
    ≥98%
  • J8800

    JW55

    TNKS1/2 inhibitor.
    ≥98%