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Neuromedin C is an endogenous bombesin-like peptide fragment of gastrin releasing peptide (GRP) that exhibits anorexigenic activity. Neuromedin C increases latency to feeding and decreases food intake and feeding time in vivo. Neuromedin C also induces scratching behavior by activating BB2 receptors and causing mast cell degranulation. Additionally, this peptide displays cardiomodulatory activity, inducing bradycardia and delaying gastric emptying.
| Cas No. | 81608-30-2 |
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| Purity | ≥98% |
| Formula | C50H73N17O11S |
| Formula Wt. | 1120.3 |
| IUPAC Name | (2S)-2-[(2-aminoacetyl)amino]-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[ [(2S)-1-[[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]- 4-methyl-1-oxopentan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl] amino]-2-oxoethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxopropan-2- yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl) -1-oxopropan-2-yl]butanediamide |
| Synonym | Bombesin decapeptide, Gastrin releasing peptide, GRP |
| Solubility | Soluble in water. |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| Info Sheet |
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Sayegh AI. The role of bombesin and bombesin-related peptides in the short-term control of food intake. Prog Mol Biol Transl Sci. 2013;114:343-70. PMID: 23317790.
Andoh T, Kuwazono T, Lee JB, et al. Gastrin-releasing peptide induces itch-related responses through mast cell degranulation in mice. Peptides. 2011 Oct;32(10):2098-103. PMID: 21933692.
Fekete EM, Bagi EE, Tóth K, et al. Neuromedin C microinjected into the amygdala inhibits feeding. Brain Res Bull. 2007 Jan 9;71(4):386-92. PMID: 17208656.