Neomycin Sulfate

Name: Neomycin Sulfate
SKU: N1755
Availability: InStock

Product ID N1755

Cas No. 1405-10-3

Purity ≥98%

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Description

Neomycin is a polycationic aminoglycoside antibiotic that exhibits antibacterial and neuromodulatory activities; it was originally found in species of Streptomyces. Neomycin binds to 23S rRNA, constraining tRNA in the P-site, inhibiting translocation and ribosomal recycling; together, this results in inhibition of protein synthesis. Neomycin B binds and inhibits bacterial RNase P and bacterial T box antiterminator RNA. Neomycin B inhibits mammalian RNA splicing as well. Neomycin also noncompetitively inhibits cation channels, including P2X receptors and transient receptor potential vanilloid receptor 1 (TRPV1) channels. Additionally, this compound inhibits Ca2+ influx, preventing presynaptic release of acetylcholine and norepinephrine in feline superior cervical ganglia.

Product Info

Cas No.	1405-10-3
Purity	≥98%
Formula	C₂₃H₄₆N₆O₁₃ • H₂SO₄
Formula Wt.	908.9
IUPAC Name	5-amino-2-(aminomethyl)-6-[4,6-diamino-2-[4-[3-amino-6-(aminomethyl)-4, 5-dihydroxyoxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3- hydroxycyclohexyl]oxyoxane-3,4-diol;sulfuric acid
Solubility	Soluble in water (1 g/mL).
Appearance	off-white powder

Shipping and Storage

Store Temp	Ambient
Ship Temp	Ambient

Downloads

MSDS	N1755 MSDS PDF
Info Sheet	N1755 Info Sheet PDF

References

Wang L, Pulk A, Wasserman MR, et al. Allosteric control of the ribosome by small-molecule antibiotics. Nat Struct Mol Biol. 2012 Sep;19(9):957-63. PMID: 22902368.

Bongartz EV, Rettinger J, Hausmann R. Aminoglycoside block of P2X2 receptors heterologously expressed in Xenopus laevis oocytes. Purinergic Signal. 2010 Dec;6(4):393-403. PMID: 21437010.

Aukema KG, Chohan KK, Plourde GL, et al. Small molecule inhibitors of yeast pre-mRNA splicing. ACS Chem Biol. 2009 Sep 18;4(9):759-68. PMID: 19634919.

Anupam R, Denapoli L, Muchenditsi A, et al. Identification of neomycin B-binding site in T box antiterminator model RNA. Bioorg Med Chem. 2008 Apr 15;16(8):4466-70. PMID: 18329274.

Kawamoto SA, Sudhahar CG, Hatfield CL, et al. Studies on the mechanism of inhibition of bacterial ribonuclease P by aminoglycoside derivatives. Nucleic Acids Res. 2008 Feb;36(2):697-704. PMID: 18084035.

Raisinghani M, Premkumar LS. Block of native and cloned vanilloid receptor 1 (TRPV1) by aminoglycoside antibiotics. Pain. 2005 Jan;113(1-2):123-33. PMID: 15621372.

Wright JM, Collier B. The effects of neomycin upon transmitter release and action. J Pharmacol Exp Ther. 1977 Mar;200(3):576-87. PMID: 191590.

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Neomycin Sulfate

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Description

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