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Necrostatin-1 is an inhibitor of receptor interacting protein 1 (RIP1), preventing necroptosis, a programmed cell death. Necrostatin-1 exhibits nephroprotective, neuroprotective, and cytoprotective activities. In animal models of chronic kidney disease, necrostatin-1 improves renal function and pathology by preventing loss of renal cells. Necrostatin-1 also prevents death of hippocampal neurons in animal models of cerebral ischemia.
| Cas No. | 4311-88-0 |
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| Purity | ≥99% |
| Formula | C13H13N3OS |
| Formula Wt. | 259.33 |
| IUPAC Name | 5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone |
| Solubility | Soluble in DMSO (10-25 mg/ml), 100% ethanol (6 mg/ml), and methanol (5 mg/ml). |
| Appearance | Off-white to yellow powder |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Zhu Y, Cui H, Gan H, et al. Necroptosis mediated by receptor interaction protein kinase 1 and 3 aggravates chronic kidney injury of subtotal nephrectomised rats. Biochem Biophys Res Commun. 2015 Jun 12;461(4):575-81. PMID: 25907058.
Yin B, Xu Y, Wei RL, et al. Inhibition of receptor-interacting protein 3 upregulation and nuclear translocation involved in Necrostatin-1 protection against hippocampal neuronal programmed necrosis induced by ischemia/reperfusion injury. Brain Res. 2015 Jun 3;1609:63-71. PMID: 25801119.
Steinwascher S, Nugues AL, Schoeneberger H, et al. Identification of a novel synergistic induction of cell death by Smac mimetic and HDAC inhibitors in acute myeloid leukemia cells. Cancer Lett. 2015 May 28. [Epub ahead of print]. PMID: 26028172.