| Product Unit Size | Cost | Quantity | Stock |
|---|
Methotrexate is an antimetabolite that exhibits immunosuppressive, abortifacient, anti-inflammatory, and anticancer chemotherapeutic activities. Methotrexate is clinically used to treat various cancers, ectopic pregnancy, and rheumatoid arthritis. Methotrexate inhibits dihydrofolate reductase, preventing thymidine, DNA, and RNA synthesis. In vivo, methotrexate increases T cell apoptosis, decreases T cell activation, and suppresses cytokine production. TEST!!!!!!
| Cas No. | 6745-93-3 |
|---|---|
| Purity | ≥98% |
| Formula | C20H22N8O5 • H2O |
| Formula Wt. | 472.45 |
| Chemical Name | N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methyl- amino]benzoyl]-L-glutamic acid |
| IUPAC Name | (2S)-2-[[4-[(2, 4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid |
| Synonym | L-(+)-Amethopterin Dihydrate, Amethopterin, MTX, Emtexate, Ledertrexate, Rheumatrex |
| Melting Point | 185-204°C(dec.) |
| Solubility | Not soluble in water or ethanol. Soluble in dilute HCl and in alkaline soln. |
| Appearance | Yellow Crystal Powder |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | |
|---|---|
| Info Sheet |
Herfarth HH, Long MD, Isaacs KL. Methotrexate: underused and ignored? Dig Dis. 2012;30 Suppl 3:112-8. doi: 10.1159/000342735. PMID: 23295701.
Mol F, Mol BW, Ankum WM, et al. Current evidence on surgery, systemic methotrexate and expectant management in the treatment of tubal ectopic pregnancy: a systematic review and meta-analysis. Hum Reprod Update. 2008 Jul-Aug;14(4):309-19. PMID: 18522946.
Wessels JA, Huizinga TW, Guchelaar HJ. Recent insights in the pharmacological actions of methotrexate in the treatment of rheumatoid arthritis. Rheumatology (Oxford). 2008 Mar;47(3):249-55. PMID: 18045808.