LKT Labs

Biochemicals for Life Science Research

Memantine Hydrochloride

Memantine Hydrochloride

Product ID M1749
Cas No. 41100-52-1
Purity ≥97%
Product Unit SizeCostQuantityStock
25 mg $60.70 In stock
100 mg $182.00 In stock
Bulk Quote

Quicklinks

Description

Memantine is an inhibitor of NMDA receptors that exhibits neuroprotective and cognition enhancing activities and is clinically used to treat Alzheimer’s disease, dementia, and Parkinson’s disease. Memantine also inhibits 5-HT3 receptors and α7 nicotinic acetylcholine receptors (nAChRs) and activates D2 receptors. Memantine improves spatial learning and memory impairments in various animal models and clinical settings. Additionally, memantine stimulates dendritic spine maturation and synapse formation in vivo.

Product Info

Cas No.

41100-52-1
Purity

≥97%
Formula

C12H21N • HCl
Formula Wt.

215.77
Chemical Name

3,5-Dimethyltricyclo[3.3.1.13,7]decan-1-amine hydrochloride
IUPAC Name

3,5-dimethyladamantan-1-amine;hydrochloride
Synonym

Akatinol
Melting Point

258°C
Solubility

Soluble in water.

Appearance

White or off-white crystals or crystalline powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

M1749 MSDS PDF
Info Sheet

M1749 Info Sheet PDF
Brochure

Memantine Flyer

References

Liu MY, Wang S, Yao WF, et al. Memantine improves spatial learning and memory impairments by regulating NGF signaling in APP/PS1 transgenic mice. Neuroscience. 2014 Jul 25;273:141-51. PMID: 24846616.

Wei H, Dobkin C, Sheikh AM, et al. The therapeutic effect of memantine through the stimulation of synapse formation and dendritic spine maturation in autism and fragile X syndrome. PLoS One. 2012;7(5):e36981. PMID: 22615862.

Aarsland D, Ballard C, Walker Z, et al. Memantine in patients with Parkinson's disease dementia or dementia with Lewy bodies: a double-blind, placebo-controlled, multicentre trial. Lancet Neurol. 2009 Jul;8(7):613-8. PMID: 19520613.

Seeman P, Caruso C, Lasaga M. Memantine agonist action at dopamine D2High receptors. Synapse. 2008 Feb;62(2):149-53. PMID: 18000814.

Aracava Y, Pereira EF, Maelicke A, et al. Memantine blocks alpha7* nicotinic acetylcholine receptors more potently than n-methyl-D-aspartate receptors in rat hippocampal neurons. J Pharmacol Exp Ther. 2005 Mar;312(3):1195-205. PMID: 15522999.

Rammes G, Rupprecht R, Ferrari U, et al. The N-methyl-D-aspartate receptor channel blockers memantine, MRZ 2/579 and other amino-alkyl-cyclohexanes antagonise 5-HT(3) receptor currents in cultured HEK-293 and N1E-115 cell systems in a non-competitive manner. Neurosci Lett. 2001 Jun 22;306(1-2):81-4. PMID: 11403963.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • A5280

    Angiotensin II (3-8), human

    Endogenous peptide fragment, involved in vasoconst...
    ≥95%
  • G4634

    Glipizide

    Sulfonylurea; ATP-sensitive K+ channel blocker.
    ≥98%
  • P004094

    N-Cinnamoyl-N-debenzoyl Paclitaxel

    N-Cinnamoyl-N-debenzoyl Paclitaxel is a paclitaxel...
    ≥95%
  • A5034

    4-Aminosalicylic Sodium Dihydrate

    Dihydrofolate reductase inhibitor.
    ≥98%
  • E0073

    Ebselen

    Synthetic glutathione peroxidase mimetic; yeast sp...
    ≥98%
  • D3218

    Diethylstilbestrol

    Synthetic non-steroid endocrine disrupter; ER agon...
    ≥98%
  • A5476

    Antagonist G

    Peptide, used for drug delivery targeting.
    ≥95%
  • R8179

    Rutaecarpine, synthetic

    Found in Evodia rutaecarpa; potential cAMP, 3β-HS...
    ≥98%
  • L1340

    LDK378

    ALK and IGF-1R inhibitor.
    ≥99%
  • T6933

    Trichostatin A

    HDAC inhibitor, mammalian RNA splicing modulator.
    ≥98%
  • D0260

    DAPT

    γ-Secretase inhibitor.
    ≥98%
  • T0253

    Tangeretin

    Polymethoxy flavonoid found in citrus fruits.
    ≥98%
  • M3196

    MHY-1485

    mTOR activator.
    ≥98%
  • V3476

    Vitamin D2

    Vitamin D prodrug produced by fungi and alfalfa.
    ≥91%
  • H9863

    Hyperforin Dicyclohexylammonium

    Stable salt form of hyperforin, a compound found i...
    ≥97%
  • A5285

    [Ile7]-Angiotensin III

    Peptide, derivative of AT III, cleavage product of...
    ≥95%
  • S7868

    SRT1720 Hydrochloride

    SIRT 1 activator, SIRT3 inhibitor.
    ≥98%
  • F1652

    Fenbufen

    NSAID; COX-1/2 inhibitor.
    ≥98%
  • P2515

    3-Phenylpropyl Isothiocyanate

    Synthetic ITC.
    ≥98%
  • Z5653

    Zonisamide

    Sulfonamide; carbonic anhydrase inhibitor, voltage...
    ≥96%