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Melphalan is a nitrogen mustard alkylator and a derivative of mechlorethamine. Melphalan exhibits anticancer chemotherapeutic activity, attaching alkyl groups to the N7 nitrogen of guanine bases on DNA, preventing DNA and RNA synthesis. TEST!!!!!!
| Cas No. | 148-82-3 |
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| Purity | ≥94% |
| Formula | C13H18Cl2N2O2 |
| Formula Wt. | 305.20 |
| Chemical Name | 4-[Bis(2-chloroethyl)amino]-L-phenylalanine |
| IUPAC Name | (2S)-2-amino-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoic acid |
| Synonym | L-PAM, L-Phenylalanine mustard, L-Sarcolysine, Alkeran, Sarcoclorin |
| Melting Point | 180-181°C |
| Solubility | Soluble in ethanol or propylene glycol. Practically insoluble in water. |
| Appearance | White to Yellow Powder |
| Store Temp | 4°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Polavarapu A, Stillabower JA, Stubblefield SG, et al. The mechanism of guanine alkylation by nitrogen mustards: a computational study.
J Org Chem. 2012 Jul 20;77(14):5914-21. PMID: 22681226.
Falco P, Bringhen S, Avonto I, et al. Melphalan and its role in the management of patients with multiple myeloma.
Expert Rev Anticancer Ther. 2007 Jul;7(7):945-57. PMID: 17627453.