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Melanin-concentrating hormone (MCH) is an endogenous peptide hormone that regulates energy homeostasis, feeding behavior, and circadian rhythms; it exhibits orexigenic and pro-inflammatory activities. MCH increases feeding behavior in animals and inhibits IL-10 expression, modulating inflammation. Increases in MCH expression are linked to irritable bowel syndrome (IBS).
| Cas No. | 128315-56-0 |
|---|---|
| Purity | ≥98% |
| Formula | C105H160N30O26S4 |
| Formula Wt. | 2386.8 |
| Synonym | MCH |
| Solubility | Soluble in water (1 mg/mL). |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| Info Sheet |
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Palomba M, Seke Etet PF, Veronesi C. Effect of inflammatory challenge on hypothalamic neurons expressing orexinergic and melanin-concentrating hormone. Neurosci Lett. 2014 Jun 6;570:47-52. PMID: 24708924.
Ziogas DC, Karagiannis AK, Geiger BM, et al. Inflammation-induced functional connectivity of melanin-concentrating hormone and IL-10. Peptides. 2014 May;55:58-64. PMID: 24556508.
Verret L, Goutagny R, Fort P, et al. A role of melanin-concentrating hormone producing neurons in the central regulation of paradoxical sleep. BMC Neurosci. 2003 Sep 9;4:19. PMID: 12964948.