LKT Labs

Biochemicals for Life Science Research

Maprotiline Hydrochloride

Maprotiline Hydrochloride

Product ID M0262
Cas No. 10347-81-6
Purity ≥98%
Product Unit SizeCostQuantityStock
1 g $44.80 In stock
5 g $180.00 In stock
Bulk Quote

Quicklinks

Description

Maprotiline is a tetracyclic antidepressant that also exhibits sedative, anxiolytic, sympathomimetic, and anticancer activities. Maprotiline acts as an antagonist at norepinephrine transporters (NET), H1 histamine receptors, 5-HT2 receptors, α1-adrenergic receptors, muscarinic acetylcholine receptors (mAChRs), and L-type Ca2+ channels. Maprotiline induces caspase-mediated apoptosis in neuroblastoma cells, inhibiting cell viability in a JNK- and ERK-dependent manner. This compound also acts as a functional inhibitor of acid sphingomyelinase (FIASMA).

Product Info

Cas No.

10347-81-6
Purity

≥98%
Formula

C20H23N • HCl
Formula Wt.

313.87
Chemical Name

N-Methyl-9.10-ethanoanthracene-9(10H)-propanamine hydrochloride
Synonym

Deprilept, Ludiomil, Psymion
Melting Point

230-232°C

Solubility

Soluble in methanol and chloroform. Slightly soluble in water.

Appearance

A White or Almost White Crystalline Powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

M0262 MSDS PDF
Info Sheet

M0262 Info Sheet PDF

References

Jan CR, Su JA, Teng CC, et al. Mechanism of maprotiline-induced apoptosis: role of [Ca2+](i), ERK, JNK and caspase-3 signaling pathways. Toxicology. 2013 Feb 8;304:1-12. PMID: 23219590.

Zahradník I, Minarovic I, Zahradníková A. Inhibition of the cardiac L-type calcium channel current by antidepressant drugs. J Pharmacol Exp Ther. 2008 Mar;324(3):977-84. PMID: 18048694.

Mayers AG, Baldwin DS. Antidepressants and their effect on sleep. Hum Psychopharmacol. 2005 Dec;20(8):533-59. PMID: 16229049.

Muscat R, Papp M, Willner P. Reversal of stress-induced anhedonia by the atypical antidepressants, fluoxetine and maprotiline. Psychopharmacology (Berl). 1992;109(4):433-8. PMID: 1365858.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • B0110

    Baclofen

    GABA derivative; GABA-B agonist.
    ≥98%
  • A5202

    Anabasine Hydrochloride

    Alkaloid originally found in species of Nicotiana,...
    ≥98%
  • W4096

    WKYMVM-NH2

    Synthetic peptide; FPRL1 agonist.
    ≥95%
  • F4445

    (R)-FSL-1

    Adjuvant; TLR2/6 agonist.
    ≥98%
  • O4533

    Oligomycin

    Mixture of oligomycins A, B, C; oxidative phosphor...
    ≥97%
  • S5745

    [Tyr1]-Somatostatin

    Endogenous neuropeptide hormone; somatostatin agon...
    ≥95%
  • E6356

    Epothilone D

    Microtubule depolymerization inhibitor.
    ≥98%
  • C1868

    Cerebellin

    Peptide, involved in synapse formation and cell ad...
    ≥95%
  • G3352

    Ginkgolic Acid (13:0)

    Alkylphenol found in Ginkgo; HIV protease inhibito...
    ≥98%
  • T7044

    Triamcinolone Acetonide Acetate

    Steroid; glucocorticoid agonist.
    ≥97%
  • I0800

    IC-87114

    p110δ PI3K inhibitor.
    ≥98%
  • C9602

    Cyanopeptolin 1041

    Toxin produced by Microcystis; serine protease inh...
    ≥95%
  • R5773

    Rosiglitazone

    Thiazolidinedione; PPARγ agonist.
    ≥98%
  • C3472

    Cisatracurium Besylate

    Non-depolarizing NMJ blocker; nAChR and M2 mAChR a...
    ≥98%
  • L1980

    Leucokinin I

    Peptide found in insects.
    ≥95%
  • H9718

    2-Hydroxyflutamide

    Non-steroid; AR antagonist.
    ≥98%
  • C4646

    Clofarabine

    Nucleoside (adenosine) analog; DNA chain terminato...
    ≥98%
  • J5237

    JNJ-26854165

    MDM2 inhibitor.
    ≥98%
  • E6231

    (−)-Epicatechin

    Flavanol originally found in Camilla (green tea).
    ≥93%
  • G4634

    Glipizide

    Sulfonylurea; ATP-sensitive K+ channel blocker.
    ≥98%