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Manidipine is a dihydropyridine inhibitor of L-type and T-type voltage-gated Ca2+ channels that decreases systemic blood pressure, glomerular capillary pressure, and renal vascular resistance, and increases renal blood flow in spontaneously hypertensive rats. In addition to its antihypertensive activity, manidipine also exhibits anti-inflammatory benefit; in epithelial cells and macrophages, manidipine inhibits activation of NF-κB and production of IL-6 and IL-8.
| Cas No. | 89226-75-5 |
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| Purity | ≥98% |
| Formula | C35H38N4O6 • 2HCl |
| Formula Wt. | 683.62 |
| IUPAC Name | 5-O-[2-(4-benzhydrylpiperazin-1-yl)ethyl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3, 5-dicarboxylate;dihydrochloride |
| Synonym | CV-4093 |
| Solubility | DMSO (21 mg/mL) |
| Appearance | Light Yellow Crystal Powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Costa S, Zimetti F, Pedrelli M, et al. Manidipine reduces pro-inflammatory cytokines secretion in human endothelial cells and macrophages. Pharmacol Res. 2010 Sep;62(3):265-70. PMID: 20347984.
Hayashi K, Ozawa Y, Fujiwara K, et al. Role of actions of calcium antagonists on efferent arterioles--with special references to glomerular hypertension. Am J Nephrol. 2003 Jul-Aug;23(4):229-44. PMID: 12840599.
Onuki T. Effects of a calcium channel blocker, manidipine hydrochloride, on the regulatory mechanism of glomerular capillary pressure in SHR. Nihon Jinzo Gakkai Shi. 1995 Feb;37(2):119-26. PMID: 7752503.