Lopinavir

Name: Lopinavir
SKU: L5862
Availability: InStock

Product ID L5862

Cas No. 192725-17-0

Purity ≥98%

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Description

Lopinavir is an HIV protease inhibitor that displays antiviral and anticancer activities. In vitro, lopinavir inhibits sarco/endoplasmic reticulum Ca2+-ATPase (SERCA), decreasing intracellular Ca2+ levels. In vivo, lopinavir’s inhibition of SERCA induces endoplasmic reticulum stress. In human papilloma virus (HPV)-positive cervical cancer cells, lopinavir upregulates ribonuclease L protein (RNASEL), potentially inducing cell death. In meningioma cells, lopinavir induces cell cycle arrest and inhibits cell growth.

Product Info

Cas No.	192725-17-0
Purity	≥98%
Formula	C₃₇H₄₈N₄O₅
Formula Wt.	628.81
IUPAC Name	(2S)-N-[(2S,4S,5S)-5-[[2-(2,6-dimethylphenoxy)acetyl]amino]-4-hydroxy-1, 6-diphenylhexan-2-yl]-3-methyl-2-(2-oxo-1,3-diazinan-1-yl)butanamide InChI: InChI=1S/C37H48N4O5/c1-25(2)34(41-20-12-19-38-37(41)45)36(44)39-30(21- 28-15-7-5-8-16-28)23-32(42)31(22-29-17-9-6-10-18-29)40-33(43)24-46-35-26 (3)13-11-14-27(35)4/h5-11,13-18,25,30-32,34,42H,12,19-24H2,1-4H3,(H,38, 45)(H,39,44)(H,40,43)/t30-,31-,32-,34-/m0/s1
Solubility	DMSO to 126 mg/mL, ethanol to 126 mg/mL, ethyl acetate
Appearance	White to off white powder

Shipping and Storage

Store Temp	Ambient
Ship Temp	Ambient

Downloads

MSDS	L5862 MSDS PDF
Info Sheet	L5862 Info Sheet PDF
Brochures	Antivirals Booklet

References

Kao E, Shinohara M, Feng M, et al. Human immunodeficiency virus protease inhibitors modulate Ca2+ homeostasis and potentiate alcoholic stress and injury in mice and primary mouse and human hepatocytes. Hepatology. 2012 Aug;56(2):594-604. PMID: 22407670.

Batman G, Oliver AW, Zehbe I, et al. Lopinavir up-regulates expression of the antiviral protein ribonuclease L in human papillomavirus-positive cervical carcinoma cells. Antivir Ther. 2011;16(4):515-25. PMID: 21685539.

Johnson MD, O'Connell M, Pilcher W. Lopinavir inhibits meningioma cell proliferation by Akt independent mechanism. J Neurooncol. 2011 Feb;101(3):441-8. PMID: 20596751.

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Lopinavir

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