LKT Labs

Biochemicals for Life Science Research

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Lomerizine Dihydrochloride

Product ID L5751
Cas No. 101477-54-7
Purity ≥98%
Product Unit SizeCostQuantityStock
100 mg $71.70 In stock
500 mg $115.80 In stock
1 g $193.00 In stock
5 g $578.90 In stock
Bulk Quote

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Description

Lomerizine is an inhibitor of voltage-gated L-type and T-type Ca2+ channels as well as transient receptor potential (TRP5) channels. Lomerizine is clinically used to treat migraine and vertigo. Lomerizine exhibits neuroprotective benefit in animal models of amyotrophic lateral sclerosis (ALS), decreasing glutamate excitotoxicity, Ca2+ overload, and mitochondrial dysfunction. In other animal models, lomerizine protects against NMDA-induced retinal damage and neurodegeneration. TEST!!!!!!

Product Info

Cas No.

101477-54-7
Purity

≥98%
Formula

C27H30F2N2O3 • 2HCl
Formula Wt.

541.47
Chemical Name

1-[Bis(4-fluorophenyl)methyl]-4-[(2,3,4-trimethoxyphenyl)methyl]piperazine dihydrochloride
IUPAC Name

1-[bis(4-fluorophenyl)methyl]-4-[(2,3, 4-trimethoxyphenyl)methyl]piperazine;dihydrochloride
Synonym

Lomerizine dihydrochloride
Melting Point

204-207°C

Appearance

White or off-White Crystalline Powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

L5751 MSDS PDF
Info Sheet

L5751 Info Sheet PDF

References

Tran LT, Gentil BJ, Sullivan KE, et al. The voltage-gated calcium channel blocker lomerizine is neuroprotective in motor neurons expressing mutant SOD1, but not TDP-43. J Neurochem. 2014 Apr 9. [Epub ahead of print]. PMID: 24716897.

Inoue Y, Yabe T. Lomerizine therapy for the treatment of benign paroxysmal vertigo of childhood transitioning into atypical basilar migraine: A case report. Exp Ther Med. 2013 Jun;5(6):1573-1575. PMID: 23837033.

Ito Y, Nakamura S, Tanaka H, et al. Lomerizine, a Ca2+ channel blocker, protects against neuronal degeneration within the visual center of the brain after retinal damage in mice. CNS Neurosci Ther. 2010 Apr;16(2):103-14. PMID: 19788586.

Fitzgerald M, Bartlett CA, Harvey AR, Dunlop SA. Early events of secondary degeneration after partial optic nerve transection: an immunohistochemical study. J Neurotrauma. 2010 Feb;27(2):439-452. PMID: 19852581.

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