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KPT-330 is a CRM1-selective inhibitor of nuclear export (SINE) that inhibits protein trafficking from the nucleus. KPT-330 displays anticancer chemotherapeutic activity. In mesothelioma cells, this compound inhibits cell growth and induces G1 phase cell cycle arrest and apoptosis; in vivo, it suppresses tumor growth.
| Cas No. | 1421923-86-5 |
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| Purity | ≥99% |
| Formula | C17H11F6N7O |
| Formula Wt. | 443.31 |
| Chemical Name | (E)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-N'-(pyrazin-2-yl)acrylohydrazide |
| IUPAC Name | (2E)-3-{3-[3,5-Bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl}-N'-(2-pyrazinyl)acrylohydrazide |
| Synonym | Selinexor E-isomer, Selinexor trans-isomer, KPT-330 E-isomer, E-KPT-330 |
| Solubility | DMSO 88 mg/mL (198.5 mM) Ethanol 40 mg/mL (90.23 mM) Water Insoluble |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Ishizawa J, Kojima K, Hail N Jr, et al. Expression, function, and targeting of the nuclear exporter chromosome region maintenance 1 (CRM1) protein. Pharmacol Ther. 2015 Jun 3. [Epub ahead of print]. PMID: 26048327.
De Cesare M, Cominetti D, Doldi V, et al. Anti-tumor activity of selective inhibitors of XPO1/CRM1-mediated nuclear export in diffuse malignant peritoneal mesothelioma: the role of survivin. Oncotarget. 2015 May 30;6(15):13119-32. PMID: 25948791.
Parikh K, Cang S, Sekhri A, et al. Selective inhibitors of nuclear export (SINE)--a novel class of anti-cancer agents. J Hematol Oncol. 2014 Oct 15;7:78. PMID: 25316614.