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JH-II-127 is a selective inhibitor of leucine-rich repeat kinase 2 (LRRK2), a potential therapeutic target for neurodegenerative disease. It inhibits phosphorylation of Ser910 and Ser935 in both wild-type LRRK2 and the G2019S mutant. TEST!!!!!!
| Cas No. | 1700693-08-8 |
|---|---|
| Purity | ≥98% |
| Formula | C19H21ClN6O3 |
| Formula Wt. | 416.87 |
| IUPAC Name | (4-{[5-Chloro-4-(methylamino)-3H-pyrrolo[2,3-d]pyrimidin-2-yl]amino}-3-methoxyphenyl)(4-morpholinyl)methanone |
| Synonym | Pyrrolopyrimidine |
| Solubility | DMSO |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Hatcher J., Zhang J., et al. Discovery of a Pyrrolopyrimidine (JH-II-127), a Highly Potent, Selective, and Brain Penetrant LRRK2 Inhibitor. ACS Med Chem Lett. 6(5):584-9 (2015). PMID: 26005538.