Description
Isradipine is a second-generation dihydropyridine calcium channel blocker. It has been found to protect against stroke and brain ischemia in rat models of hypertension. Research has also shown that isradipine influences amyloid-beta production in addition to components of the cav1.2-ptau-autophagy pathway and thereby may be useful in the treatment of Alzheimer’s disease. Furthermore, it has been found to protect striatal dopaminergic terminals and parent substantia nigra pars compacta cell bodies against intrastriatal injection of the toxin 6-hydroxydopamine, and so may also be an effective treatment of Parkinson’s disease.
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