LKT Labs

Biochemicals for Life Science Research

Ibudilast

Ibudilast

Product ID I0480
Cas No. 50847-11-5
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $134.40 In stock
25 mg $310.10 In stock
100 mg $1,033.60 In stock
Bulk Quote

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Description

Ibudilast is an inhibitor of phosphodiesterases 3 and 5 (PDE3/5) that also inhibits the leukotriene D4 (LTD4) receptor in airway smooth muscle cells. Ibudilast exhibits vasodilatory, anti-inflammatory, anti-asthma, anti-platelet, analgesic, and antinociceptive activities. In clinical settings, ibudilast increases cerebral blood flow in several brain regions after ischemic stroke. Ibudilast also non-competitively inhibits the functions of pro-inflammatory macrophage migration inhibitory factor (MIF), preventing glial cell activation. In other cellular models, ibudilast decreases activation of NF-κB, inhibiting HIV-1 Tat-induced production of TNF-α.

Product Info

Cas No.

50847-11-5
Purity

≥98%
Formula

C14H18N2O
Formula Wt.

230.31
IUPAC Name

2-methyl-1-(2-propan-2-ylpyrazolo[1,5-a]pyridin-3-yl)propan-1-one
Synonym

3-Isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine, 2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]-1-propanone, 2-Isopropyl-3-isobutyrylpyrazolo[1,5-a]pyridine, KC-404, AV-411
Melting Point

53-54°C
Appearance

White Crystal Powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

I0480 MSDS PDF
Info Sheet

I0480 Info Sheet PDF

References

Inoue N, Fukuda S, Inada T, et al. Effect of ibudilast on the reciprocal inhibitory visual-vestibular interaction closely related to dizziness after cerebral ischemia. J Stroke Cerebrovasc Dis. 2014 Jan;23(1):51-5. PMID: 23085301.

Kiebala M, Maggirwar SB. Ibudilast, a pharmacologic phosphodiesterase inhibitor, prevents human immunodeficiency virus-1 Tat-mediated activation of microglial cells. PLoS One. 2011 Apr 8;6(4):e18633. PMID: 21494611.

Cho Y, Crichlow GV, Vermeire JJ, et al. Allosteric inhibition of macrophage migration inhibitory factor revealed by ibudilast. Proc Natl Acad Sci U S A. 2010 Jun 22;107(25):11313-8. PMID: 20534506.

Ledeboer A, Hutchinson MR, Watkins LR, et al. Ibudilast (AV-411). A new class therapeutic candidate for neuropathic pain and opioid withdrawal syndromes. Expert Opin Investig Drugs. 2007 Jul;16(7):935-50. PMID: 17594181.

Kishi Y, Ohta S, Kasuya N, et al. Ibudilast modulates platelet-endothelium interaction mainly through cyclic GMP-dependent mechanism. J Cardiovasc Pharmacol. 2000 Jul;36(1):65-70. PMID: 10892662.

Ohashi M, Kanai R, Nishino K, et al. Antagonistic effect of KC-404, a new anti-asthmatic agent, on leukotriene D4-induced contractile responses in isolated guinea pig smooth muscles. Prostaglandins. 1986 Dec;32(6):875-88. PMID: 3562868.

Ohashi M, Ohkubo H, Kito J, et al. A new vasodilator 3-isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine (KC-404) has a dual mechanism of action on platelet aggregation. Arch Int Pharmacodyn Ther. 1986 Oct;283(2):321-34. PMID: 3024600.

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