LKT Labs

Biochemicals for Life Science Research

Homoharringtonine

Homoharringtonine

Product ID H5750
Cas No. 26833-87-4
Purity ≥97%
Product Unit SizeCostQuantityStock
1 mg $44.80 In stock
5 mg $126.80 In stock
10 mg $154.40 In stock
Bulk Quote

Quicklinks

Description

Homoharringtonine is an alkaloid found in Cephalotaxus that binds the A site of the 60 S ribosomal subunit, preventing aminoacyl-tRNA binding, inhibiting protein translation, and inducing cell death; it exhibits anticancer chemotherapeutic and immunosuppressive activities. Homoharringtonine is clinically used to treat chronic myelogenous leukemia (CML) and is currently in clinical trials as a potential treatment for acute myelogenous leukemia (AML) and myelodysplastic syndrome. In clinical subjects, homoharringtonine decreases the number of CD34+, CD117+ cells.

Product Info

Cas No.

26833-87-4
Purity

≥97%
Formula

C29H39NO9
Formula Wt.

545.62
Melting Point

143-145°C
Solubility

Soluble in DMSO (50 mg/mL), ethanol (25 mg/mL). Slightly soluble in chloroform, methanol.
Appearance

White Powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

H5750 MSDS PDF
Info Sheet

H5750 Info Sheet PDF
Brochures

Natural Products Booklet

References

Gandhi V, Plunkett W, Cortes JE. Omacetaxine: a protein translation inhibitor for treatment of chronic myelogenous leukemia. Clin Cancer Res. 2014 Apr 1;20(7):1735-40. PMID: 24501394.

Daver N, Vega-Ruiz A, Kantarjian HM, et al. A phase II open-label study of the intravenous administration of homoharringtonine in the treatment of myelodysplastic syndrome. Eur J Cancer Care (Engl). 2013 Sep;22(5):605-11. PMID: 23701251.

Li YF, Deng Z, Din BH, et al. Effect of homoharringtonine on bone marrow CD34 + CD117 + cells in patients with chronic myelogenous leukemia. Leuk Lymphoma. 2012 May;53(5):934-9. PMID: 22054289.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • A4845

    Amylin (8-37), rat

    Endogenous peptide hormone inolved in gastric empt...
    ≥95%
  • A464768

    Altertoxin 1

    Mycotoxin contaminant in food and feed.
    ≥97%
  • H9862

    Hypothemycin

    Polyketide found in Setophoma.
    ≥96%
  • M5793

    Moxifloxacin Free Base

    Fluoroquinolone; topoisomerase IV, topoisomerase I...
    ≥98%
  • A9715

    AZD-8330

    MEK 1/2 inhibitor.
    ≥98%
  • S0225

    SAG Dihydrochloride

    Smoothened agonist.
    ≥98%
  • G8104

    Guanylin, rat/mouse

    Endogenous peptide hormone; guanyl cyclase C agoni...
    ≥95%
  • B5874

    Bosutinib

    Src and Abl inhibitor.
    ≥98%
  • P3076

    PHT-427

    PDK1 and Akt inhibitor.
    ≥98%
  • C4417

    Clemizole

    TRPC5 activator, NS4B and histamine H1 inhibitor.
    ≥98%
  • G6802

    Granisetron Hydrochloride

    5-HT3 antagonist.
    ≥98%
  • F4681

    Flumazenil

    GABA-A antagonist.

    ≥98%
  • V1600

    VE-821

    ATR inhibitor.
    ≥98%
  • P6850

    Prolactin-Releasing Peptide (1-31), human

    Endogenous peptide hormone, involved in hormone se...
    ≥98%
  • C0153

    Calcitonin, rat

    Endogenous neuropeptide hormone, lowers extracellu...
    ≥95%
  • A5327

    Anagrelide

    Imidazoquinazoline; PDE3 inhibitor.
    ≥98%
  • P4492

    PLX4720

    V600E B-Raf inhibitor.
    ≥98%
  • T286161

    Theaflavin

    Polyphenolic compound present in black tea.
    ≥98%
  • G6368

    GPR

    Peptide, fibrinogen E analog found in Amaranthus; ...
    ≥95%
  • P6002

    PP-121

    p110α PI3K, DNA-PK, mTOR, Abl, Hck, Src, VEGFR2, ...
    ≥98%