LKT Labs

Biochemicals for Life Science Research

Histatin 5

Histatin 5

Product ID H3273
Cas No. 115966-68-2
Purity ≥95%
Product Unit SizeCostQuantityStock
0.5 mg $239.40 In stock
1 mg $406.40 In stock
2.5 mg $718.30 In stock
Bulk Quote

Quicklinks

Description

Histatin 5 is an endogenous antimicrobial peptide (AMP) present in the salivary gland. Histatin 5 exhibits anti-inflammatory, antibacterial, and antifungal activities. In myeloid dendritic cells, histatin 5 binds Poryphyromonas hemagglutinin B, inhibiting production of MIP-1α, MIP-1β, and TNF-α. Histatin binds bacterial DNA, displaying bactericidal activity against gram positive bacteria such as Streptococcus. Additionally, histatin 5 causes ion flux-induced cell death of Candida cells in an ex vivo model of oral candidiasis.

Product Info

Cas No.

115966-68-2
Purity

≥95%
Formula

C133H195N51O33
Formula Wt.

3036.36
Solubility

Soluble in water.
Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

H3273 MSDS PDF
Info Sheet

H3273 Info Sheet PDF

References

Borgwardt DS, Martin AD, Van Hemert JR, et al. Histatin 5 binds to Porphyromonas gingivalis hemagglutinin B (HagB) and alters HagB-induced chemokine responses. Sci Rep. 2014 Jan 29;4:3904. PMID: 24473528.

Huo L, Zhang K, Ling J, et al. Antimicrobial and DNA-binding activities of the peptide fragments of human lactoferrin and histatin 5 against Streptococcus mutans. Arch Oral Biol. 2011 Sep;56(9):869-76. PMID: 21382611.

Peters BM, Zhu J, Fidel PL Jr, et al. Protection of the oral mucosa by salivary histatin-5 against Candida albicans in an ex vivo murine model of oral infection. FEMS Yeast Res. 2010 Aug 1;10(5):597-604. PMID: 20491938.

Jang WS, Bajwa JS, Sun JN, et al. Salivary histatin 5 internalization by translocation, but not endocytosis, is required for fungicidal activity in Candida albicans. Mol Microbiol. 2010 Jul;77(2):354-70. PMID: 20487276.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • C2943

    Chlorogenic Acid (from Eucommia)

    Polyphenol derivative of caffeic acid found in Euc...
    ≥98%
  • C0800

    C59

    PORCN inhibitor.
    ≥98%
  • V1745

    Veliparib

    PARP inhibitor.
    ≥99%
  • A2420

    A-769662

    AMPK activator.
    ≥98%
  • F1992

    Fexaramine

    FXR agonist.
    ≥98%
  • A6269

    Apremilast

    PDE4 inhibitor.
    ≥98%
  • P7000

    PR-619

    Deubiquitinating enzyme inhibitor.
    ≥98%
  • H189921

    1,2,3,4,5,6-Hexabromocyclohexane

    1,2,3,4,5,6-hexabromocyclohexane directly inhibits...
    ≥98%
  • I2056

    Ifosfamide

    Nitrogen mustard, DNA alkylator.
    ≥98%
  • O5212

    Ondansetron Hydrochloride Dihydrate

    5-HT3 antagonist.
    ≥98%
  • G2872

    Growth Hormone Releasing Factor, mouse

    Endogenous peptide hormone, involved in growth hor...
    ≥95%
  • A0802

    Acarbose

    α-glucosidase inhibitor.
    ≥98%
  • C2801

    Chaetoglobosin A

    Cytotoxic and antifungal activities.
    ≥99%
  • V3360

    Vasoactive Intestinal Peptide, guinea pig

    Endogenous peptide hormone, involved in enteric mo...
    ≥95%
  • L1684

    Levonorgestrel

    Synthetic progestogen; contraceptive.
    ≥98%
  • V0146

    Valsartan

    AT1 inhibitor.
    ≥98%
  • H9612

    Hydrocortisone 21-Acetate

    Steroid hormone involved in stress signaling; gluc...
    ≥98%
  • O4549

    Olmesartan Medoxomil

    AT1 inhibitor.
    ≥98%
  • N2400

    NG-52

    Purine, purvalenol A analog; CDK2, Cdc28p, Pho85p ...
    ≥98%
  • I0010

    5-(9-Isopropyl-2-morpholino-9H-purin-6-yl)pyrimidin-2-amine

    Intermediate in the synthesis of purine analogs an...
    ≥98%